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Letermovir is an antiviral medication specifically used for the prevention of cytomegalovirus (CMV) infection in CMV-seropositive hematopoietic stem cell transplant recipients. It inhibits the CMV DNA terminase complex, blocking viral replication. Letermovir is usually well tolerated and has a lower toxicity profile compared to older antivirals like ganciclovir. It can be administered orally or intravenously.
Cleanchem is a trusted provider of premium pharmaceutical reference materials, specializing in Letermovir and its associated compounds. Our catalog includes pharmacopeial and non-pharmacopeial Letermovir impurities, metabolites, nitrosamine derivatives (N-NO compounds), and stable isotope-labeled products. These reference standards play a critical role in pharmaceutical R&D, supporting activities such as product formulation, ANDA and DMF submissions, quality assurance, analytical method development, and stability assessments.
All Letermovir-related substances undergo comprehensive characterization and are delivered with complete Certificates of Analysis and supporting analytical documentation to ensure regulatory adherence. Upon request, we can offer EP/USP traceable standards. Our products are routinely re-evaluated to maintain consistent quality and performance.

N-Nitroso Letermovir Impurity 1
CAT No: CL-LRVR-NO-01 CAS No: NA Mol Wt: 640.73 Mol F: C36H40N4O7 Inv Status: Custom Synthesis
Chemical Name: 1-(3-methoxyphenyl)-4-nitrosopiperazine
N-Nitroso Letermovir Impurity 2
CAT No: CL-LRVR-NO-02 CAS No: NA Mol Wt: 626.7 Mol F: C35H38N4O7 Inv Status: Custom Synthesis
Chemical Name: (S)-2-(8-fluoro-3-(2-methoxy-5-(trifluoromethyl)phenyl)-2-(4-nitrosopiperazin-1-yl)-3,4-dihydroquinazolin-4-yl)acetic acid
N-Nitroso Letermovir Impurity 3
CAT No: CL-LRVR-NO-03 CAS No: NA Mol Wt: 427.43 Mol F: C21H22FN5O4 Inv Status: Custom Synthesis
Chemical Name: (S)-2-(8-fluoro-2-(4-(3-methoxyphenyl)piperazin-1-yl)-3-nitroso-3,4-dihydroquinazolin-4-yl)acetic acid
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