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Chlorhexidine is an antiseptic and antimicrobial agent used for skin disinfection, wound care, and as a mouthwash for gingivitis. It works by disrupting bacterial cell membranes, leading to bacterial death. Chlorhexidine is commonly used in surgical settings for preoperative skin preparation and for the prevention of oral infections. Side effects may include skin irritation, staining of teeth, and allergic reactions.
Cleanchem is a trusted provider of premium pharmaceutical reference materials, specializing in Chlorhexidine and its associated compounds. Our catalog includes pharmacopeial and non-pharmacopeial Chlorhexidine impurities, metabolites, nitrosamine derivatives (N-NO compounds), and stable isotope-labeled products. These reference standards play a critical role in pharmaceutical R&D, supporting activities such as product formulation, ANDA and DMF submissions, quality assurance, analytical method development, and stability assessments.
All Chlorhexidine-related substances undergo comprehensive characterization and are delivered with complete Certificates of Analysis and supporting analytical documentation to ensure regulatory adherence. Upon request, we can offer EP/USP traceable standards. Our products are routinely re-evaluated to maintain consistent quality and performance.

N-Nitroso Chlorhexidine Impurity E
CAT No: CL-CHDC-NO-01 CAS No: NA Mol Wt: 198.61 Mol F: C7H7ClN4O Inv Status: Custom Synthesis
Chemical Name: 1-(4-chlorophenyl)-1-nitrosoguanidine
N-Nitroso Chlorhexidine Impurity 1
CAT No: CL-CHDC-NO-02 CAS No: NA Mol Wt: 198.61 Mol F: C7H7ClN4O Inv Status: Custom Synthesis
Chemical Name: (E)-1-(4-chlorophenyl)-2-nitrosoguanidine
N-Nitroso Chlorhexidine Impurity F
CAT No: CL-CHDC-NO-03 CAS No: NA Mol Wt: 199.59 Mol F: C7H6ClN3O2 Inv Status: Custom Synthesis
Chemical Name: 1-(4-chlorophenyl)-1-nitrosourea
N-Nitroso Chlorhexidine Impurity L
CAT No: CL-CHDC-NO-04 CAS No: NA Mol Wt: 359.72 Mol F: C13H14ClN3O7 Inv Status: Custom Synthesis
Chemical Name: N-(4-chlorophenyl)-N-((5R,6S)-5-hydroxy-4-oxo-6-((1R,2R)-1,2,3-trihydroxypropyl)-5,6-dihydro-4H-1,3-oxazin-2-yl)nitrous amide
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