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Voxelotor is a hemoglobin modulator approved for the treatment of sickle cell disease. It works by increasing hemoglobin's affinity for oxygen, which helps inhibit the polymerization of sickled hemoglobin and thereby reduces hemolysis and anemia. Voxelotor improves hemoglobin levels and reduces markers of hemolytic activity. It represents a disease-modifying treatment that targets the root cause of sickling in red blood cells.
Cleanchem is a trusted provider of premium pharmaceutical reference materials, specializing in Voxelotor and its associated compounds. Our catalog includes pharmacopeial and non-pharmacopeial Voxelotor impurities, metabolites, nitrosamine derivatives (N-NO compounds), and stable isotope-labeled products. These reference standards play a critical role in pharmaceutical R&D, supporting activities such as product formulation, ANDA and DMF submissions, quality assurance, analytical method development, and stability assessments.
All Voxelotor-related substances undergo comprehensive characterization and are delivered with complete Certificates of Analysis and supporting analytical documentation to ensure regulatory adherence. Upon request, we can offer EP/USP traceable standards. Our products are routinely re-evaluated to maintain consistent quality and performance.

Voxelotor
CAT No: CL-VOXE-01 CAS No: 1446321-46-5 Mol Wt: 337.4 Mol F: C19H19N3O3 Inv Status: Custom Synthesis
Chemical Name:  2-Hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde
Voxelotor Impurity 1
CAT No: CL-VOXE-02 CAS No:  1282518-60-8 Mol Wt: 236.1 Mol F: C12H21BN2O2 Inv Status: Custom Synthesis
Chemical Name: 1-Isopropyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
Voxelotor Impurity 2
CAT No: CL-VOXE-03 CAS No: 84290-49-3 Mol Wt: 182.2 Mol F: C9H10O4 Inv Status: Custom Synthesis
Chemical Name: 2-Hydroxy-6-(methoxymethoxy)benzaldehyde
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