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Tepotinib is a selective MET tyrosine kinase inhibitor that blocks signaling pathways involved in tumor cell growth and survival. It is used in the treatment of non-small cell lung cancer with MET exon 14 skipping alterations. By inhibiting MET, it disrupts oncogenic signaling and helps reduce tumor progression.
Cleanchem is a trusted provider of premium pharmaceutical reference materials, specializing in Tepotinib and its associated compounds. Our catalog includes pharmacopeial and non-pharmacopeial Tepotinib impurities, metabolites, nitrosamine derivatives (N-NO compounds), and stable isotope-labeled products. These reference standards play a critical role in pharmaceutical R&D, supporting activities such as product formulation, ANDA and DMF submissions, quality assurance, analytical method development, and stability assessments.
All Tepotinib-related substances undergo comprehensive characterization and are delivered with complete Certificates of Analysis and supporting analytical documentation to ensure regulatory adherence. Upon request, we can offer EP/USP traceable standards. Our products are routinely re-evaluated to maintain consistent quality and performance.

Tepotinib
CAT No: CL-TPNB-01 CAS No: 1100598-32-0 Mol Wt: 492.6 Mol F: C29H28N6O2 Inv Status: Custom Synthesis
Chemical Name: 3-(1-(3-(5-((1-Methylpiperidin-4-yl)methoxy)pyrimidin-2-yl)benzyl)-6-oxo-1,6-dihydropyridazin-3-yl)benzonitrile
Tepotinib M506 Metabolite
CAT No: CL-TPNB-02 CAS No: NA Mol Wt: 506.6 Mol F: C29H26N6O3 Inv Status: Custom Synthesis
Chemical Name: 3-(1-(3-(5-((1-Methyl-2-oxopiperidin-4-yl)methoxy)pyrimidin-2-yl)benzyl)-6-oxo-1,6-dihydropyridazin-3-yl)benzonitrile
Tepotinib Impurity 1
CAT No: CL-TPNB-03 CAS No: 1100598-47-7 Mol Wt: 427.5 Mol F: C23H29N3O5 Inv Status: Custom Synthesis
Chemical Name: Tert-butyl 4-(((2-(3-(methoxycarbonyl)phenyl)pyrimidin-5-yl)oxy)methyl)piperidine-1-carboxylate
Tepotinib Impurity 2
CAT No: CL-TPNB-04 CAS No: 1103506-77-9 Mol Wt: 444.3 Mol F: C22H14BrN5O Inv Status: Custom Synthesis
Chemical Name: 3-(1-(3-(5-Bromopyrimidin-2-yl)benzyl)-6-oxo-1,6-dihydropyridazin-3-yl)benzonitrile
Tepotinib Impurity 3
CAT No: CL-TPNB-05 CAS No: 1103506-79-1 Mol Wt: 381.4 Mol F: C22H15N5O2 Inv Status: Custom Synthesis
Chemical Name: 3-(1-(3-(5-Hydroxypyrimidin-2-yl)benzyl)-6-oxo-1,6-dihydropyridazin-3-yl)benzonitrile
Tepotinib Impurity 4
CAT No: CL-TPNB-06 CAS No: 1103506-80-4 Mol Wt: 578.7 Mol F: C33H34N6O4 Inv Status: Custom Synthesis
Chemical Name: Tert-butyl 4-(((2-(3-((3-(3-cyanophenyl)-6-oxopyridazin-1(6H)-yl)methyl)phenyl)pyrimidin-5-yl)oxy)methyl)piperidine-1-carboxylate
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