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Cleanchem is a trusted provider of premium pharmaceutical reference materials, specializing in Sorafenib and its associated compounds. Our catalog includes pharmacopeial and non-pharmacopeial Sorafenib impurities, metabolites, nitrosamine derivatives (N-NO compounds), and stable isotope-labeled products. These reference standards play a critical role in pharmaceutical R&D, supporting activities such as product formulation, ANDA and DMF submissions, quality assurance, analytical method development, and stability assessments.
All Sorafenib-related substances undergo comprehensive characterization and are delivered with complete Certificates of Analysis and supporting analytical documentation to ensure regulatory adherence. Upon request, we can offer EP/USP traceable standards. Our products are routinely re-evaluated to maintain consistent quality and performance.

Sorafenib

CAT No: CL-SFNB-01 CAS No: 284461-73-0 Mol Wt: 464.8 Mol F: C21H16ClF3N4O3 Inv Status: Custom Synthesis

Chemical Name: 4-[4-[[[4-Chloro-3-(trifluoromethyl)phenyl]carbamoyl]amino]phenoxy]-N-methylpyridine-2-carboxamide

Sorafenib Related Compound

CAT No: CL-SFNB-02 CAS No: 2004659-85-0 Mol Wt: 228.3 Mol F: C13H12N2O2 Inv Status: Custom Synthesis

Chemical Name: N-Methyl-4-phenoxypicolinamide

Sorafenib EP Impurity G

CAT No: CL-SFNB-03 CAS No: 18585-06-3 Mol Wt: 267.6 Mol F: C10H9ClF3NO2 Inv Status: Custom Synthesis

Chemical Name: Ethyl [4-chloro-3-(trifluoromethyl)phenyl]carbamate

Sorafenib EP Impurity F

CAT No: CL-SFNB-04 CAS No: 1285533-84-7 Mol Wt: 430.4 Mol F: C21H17F3N4O3 Inv Status: Custom Synthesis

Chemical Name: N-Methyl-4-[4-[[[3-(trifluoromethyl)phenyl]carbamoyl]amino]phenoxy]pyridine-2-carboxamide N-Methyl-4-{4-[3-(3-trifluoromethylphenyl)ureido]phenoxy}picolinamide (as per USP)

Sorafenib EP Impurity C

CAT No: CL-SFNB-05 CAS No: 320-51-4 Mol Wt: 195.6 Mol F: C7H5ClF3N Inv Status: Custom Synthesis

Chemical Name: 4-Chloro-3-(trifluoromethyl)aniline (as per EP & USP)

Sorafenib EP Impurity F Hydrochloride

CAT No: CL-SFNB-06 CAS No: 1285534-09-9 Mol Wt: 430.4 Mol F: C21H17F3N4O3 Inv Status: Custom Synthesis

Chemical Name: N-Methyl-4-[4-[[[3-(trifluoromethyl)phenyl]carbamoyl]amino]phenoxy]pyridine-2-carboxamide N-Methyl-4-{4-[3-(3-trifluoromethylphenyl)ureido]phenoxy}picolinamide (as per USP)

Sorafenib EP Impurity D

CAT No: CL-SFNB-07 CAS No: NA Mol Wt: 329.4 Mol F: C17H19N3O4 Inv Status: Custom Synthesis

Chemical Name: Propan-2-yl [4-[[2-(methylcarbamoyl)pyridin-4-yl]oxy]phenyl]carbamate Isopropyl (4-((2-(methylcarbamoyl)pyridin-4-yl)oxy)phenyl)carbamate (as per USP)

Sorafenib Related Compound 7

CAT No: CL-SFNB-08 CAS No: 2206827-12-3 Mol Wt: 315.3 Mol F: C16H17N3O4 Inv Status: Custom Synthesis

Chemical Name: Ethyl (4-((2-(methylcarbamoyl)pyridin-4-yl)oxy)phenyl)carbamate

Sorafenib EP Impurity F Tosylate

CAT No: CL-SFNB-09 CAS No: 1285534-33-9 Mol Wt: 430.4 Mol F: C21H17F3N4O3 Inv Status: Custom Synthesis

Chemical Name: N-Methyl-4-[4-[[[3-(trifluoromethyl)phenyl]carbamoyl]amino]phenoxy]pyridine-2-carboxamide N-Methyl-4-{4-[3-(3-trifluoromethylphenyl)ureido]phenoxy}picolinamide (as per USP)

Sorafenib EP Impurity C Hydrochloride

CAT No: CL-SFNB-10 CAS No: 53313-44-3 Mol Wt: 195.6 Mol F: C7H5ClF3N Inv Status: Custom Synthesis

Chemical Name: 4-Chloro-3-(trifluoromethyl)aniline (as per EP & USP)

Sorafenib EP Impurity A Hydrochloride

CAT No: CL-SFNB-11 CAS No: 911132-05-3 Mol Wt: 279.73 Mol F: C13H13N3O2.HCl Inv Status: Custom Synthesis

Chemical Name: 4-(4-aminophenoxy)-N-methyl-, hydrochloride (1:1)

N-Desmethyl Sorafenib Tosylate

CAT No: CL-SFNB-12 CAS No: 943024-27-9 Mol Wt: 450.5 Mol F: C20H14ClF3N4O3 Inv Status: Custom Synthesis

Chemical Name: 4-(4-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)phenoxy)picolinamide

Sorafenib Related Compound 12

CAT No: CL-SFNB-13 CAS No: NA Mol Wt: 464.82 Mol F: C21H16ClF3N4O3 : C7H8O3S Inv Status: Custom Synthesis

Chemical Name: 4-(4-{3-[2-Chloro-3-(trifluoromethyl)phenyl]ureido}phenoxy)-N-methylpicolinamide

Sorafenib EP Impurity E

CAT No: CL-SFNB-14 CAS No: 284670-98-0 Mol Wt: 512.5 Mol F: C27H24N6O5 Inv Status: Custom Synthesis

Chemical Name: 4,4'-[Carbonylbis(azanediyl-4,1-phenyleneoxy)]bis(N-methylpyridine-2-carboxamide) N,N?Bis{4-[2-(N-methylcarbamoyl)-4-pyridyloxy]phenyl}urea (as per USP)

Sorafenib Hydrochloride

CAT No: CL-SFNB-15 CAS No: 1199618-57-9 Mol Wt: 464.8 : 36.5 Mol F: C21H16ClF3N4O3 : HCl Inv Status: Custom Synthesis

Chemical Name: 4-[4-[[[4-Chloro-3-(trifluoromethyl)phenyl]carbamoyl]amino]phenoxy]-N-methylpyridine-2-carboxamide Hydrochloride ;4-(4-{3-[4-Chloro-3-(trifluoromethyl)phenyl]ureido}phenoxy)-N2-methylpyridine-2-carboxamide mono (Hydrochloride) (as per USP)

Sorafenib Hydrobromide

CAT No: CL-SFNB-16 CAS No: 1199618-58-0 Mol Wt: 464.8 : 80.9 Mol F: C21H16ClF3N4O3 : HBr Inv Status: Custom Synthesis

Chemical Name: 4-[4-[[[4-Chloro-3-(trifluoromethyl)phenyl]carbamoyl]amino]phenoxy]-N-methylpyridine-2-carboxamide Hydrobromide ; 4-(4-{3-[4-Chloro-3-(trifluoromethyl)phenyl]ureido}phenoxy)-N2-methylpyridine-2-carboxamide mono (Hydrobromide) (as per USP)

Sorafenib Hemi-Tosylate Monohydrate

CAT No: CL-SFNB-17 CAS No: 1908433-49-7 Mol Wt: 464.8 : 1/2(172.2) : 18.0 Mol F: C21H16ClF3N4O3 : 1/2(C7H8O3S) : H2O Inv Status: Custom Synthesis

Chemical Name: 4-[4-[[[4-Chloro-3-(trifluoromethyl)phenyl]carbamoyl]amino]phenoxy]-N-methylpyridine-2-carboxamide hemitosylate monohydrate;4-(4-{3-[4-Chloro-3-(trifluoromethyl)phenyl]ureido}phenoxy)-N2-methylpyridine-2-carboxamide hemitosylate monohydrate (as per USP)

Sorafenib EP Impurity H

CAT No: CL-SFNB-18 CAS No: 1431697-81-2 Mol Wt: 464.8 Mol F: C21H16ClF3N4O3 Inv Status: Custom Synthesis

Chemical Name: 4-[4-[[[2-chloro-3-(trifluoromethyl)phenyl]carbamoyl]amino]phenoxy]-N-methylpyridine-2-carboxamide ; 4-(4-{3-[2-Chloro-3-(trifluoromethyl)phenyl]ureido}phenoxy)-N-methylpicolinamide (as per USP)

Sorafenib N-Oxide

CAT No: CL-SFNB-19 CAS No: 583840-03-3 Mol Wt: 480.8 Mol F: C21H16ClF3N4O4 Inv Status: Custom Synthesis

Chemical Name: 4-(4-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)phenoxy)-2-(methylcarbamoyl)pyridine 1-oxide

Sorafenib Impurity I

CAT No: CL-SFNB-20 CAS No: 370-50-3 Mol Wt: 417.1 Mol F: C15H8Cl2F6N2O Inv Status: Custom Synthesis

Chemical Name: 1,3-Bis(4-chloro-3-(trifluoromethyl)phenyl)urea

Sorafenib Impurity C

CAT No: CL-SFNB-21 CAS No: 2204442-52-2 Mol Wt: 195.57 Mol F: C7H5ClF3N Inv Status: Custom Synthesis

Chemical Name: 4-Chloro-3-(trifluoromethyl)aniline (as per EP & USP)

Sorafenib Carboxylic Acid Methyl Ester

CAT No: CL-SFNB-23 CAS No: 573673-43-5 Mol Wt: 465.8 Mol F: C21H15ClF3N3O4 Inv Status: Custom Synthesis

Chemical Name: Methyl 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)phenoxy)picolinate

Sorafenib N-Desmethyl N-Oxide

CAT No: CL-SFNB-24 CAS No: 583840-04-4 Mol Wt: 466.8 Mol F: C20H14ClF3N4O4 Inv Status: Custom Synthesis

Chemical Name: 2-Carbamoyl-4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)phenoxy)pyridine 1-oxide

Sorafenib Urea Impurity

CAT No: CL-SFNB-25 CAS No: 1129683-88-0 Mol Wt: 286.3 : 1/2(98.1) Mol F: C14H14N4O3 Inv Status: Custom Synthesis

Chemical Name: N-Methyl-4-(4-ureidophenoxy)picolinamide

Sorafenib Tosylate

CAT No: CL-SFNB-26 CAS No: 475207-59-1 Mol Wt: 464.8 : 172.2 Mol F: C21H16ClF3N4O3 : C7H8O3S Inv Status: Custom Synthesis

Chemical Name: 4-[4-[[[4-Chloro-3-(trifluoromethyl)phenyl]carbamoyl]amino]phenoxy]-N-methylpyridine-2-carboxamide 4-methylbenzene-1-sulfonate ; 4-(4-{3-[4-Chloro-3-(trifluoromethyl)phenyl]ureido}phenoxy)-N2-methylpyridine-2-carboxamide mono(4-methylbenzenesulfonate) (as per USP)

N-Desmethyl Sorafenib

CAT No: CL-SFNB-27 CAS No: 284461-74-1 Mol Wt: 450.8 Mol F: C20H14ClF3N4O3 Inv Status: Custom Synthesis

Chemical Name: 4-(4-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)phenoxy)picolinamide

Sorafenib IP Impurity B

CAT No: CL-SFNB-28 CAS No: 2514724-45-7 Mol Wt: 505.3 Mol F: C25H14Cl2F4N2O Inv Status: Custom Synthesis

Chemical Name: 1,3-Bis(6-chloro-2',3'-difluoro-[1,1'-biphenyl]-3-yl)urea

Sorafenib Impurity 4

CAT No: CL-SFNB-29 CAS No: 871555-75-8 Mol Wt: 315.7 Mol F: C14H9ClF3NO2 Inv Status: Custom Synthesis

Chemical Name: Phenyl (4-chloro-3-(trifluoromethyl)phenyl)carbamate

Sorafenib Impurity 5

CAT No: CL-SFNB-30 CAS No: 88330-63-6 Mol Wt: 221.6 Mol F: C8H3ClF3NO Inv Status: Custom Synthesis

Chemical Name: 2-Chloro-1-isocyanato-3-(trifluoromethyl)benzene

Sorafenib Ethylamine Impurity

CAT No: CL-SFNB-31 CAS No: 284462-82-4 Mol Wt: 257.3 Mol F: C14H15N3O2 Inv Status: Custom Synthesis

Chemical Name: 4-(4-Aminophenoxy)-N-ethylpicolinamide

Sorafenib Hydroxydemethylamine

CAT No: CL-SFNB-32 CAS No: 1012058-78-4 Mol Wt: 451.8 Mol F: C20H13ClF3N3O4 Inv Status: Custom Synthesis

Chemical Name: 4-[4-[[[[4-Chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-2-pyridinecarboxylic Acid; 4-(4-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)phenoxy)picolinic Acid

Sorafenib Impurity 6

CAT No: CL-SFNB-33 CAS No: 284461-82-1 Mol Wt: 478.9 Mol F: C22H18ClF3N4O3 Inv Status: Custom Synthesis

Chemical Name: 4-(4-(3-(4-Chloro-3(trifluoromethyl)phenyl)ureido)phenox yl)-n-ethylpicolinamide

Sorafenib Impurity 7

CAT No: CL-SFNB-34 CAS No: 1012058-77-3 Mol Wt: 230.2 Mol F: C12H10N2O3 Inv Status: Custom Synthesis

Chemical Name: 4-(4-Aminophenoxy)picolinic acid

Sorafenib Impurity 8

CAT No: CL-SFNB-35 CAS No: 94-74-6 Mol Wt: 200.6 Mol F: C9H9ClO3 Inv Status: Custom Synthesis

Chemical Name: 2-(4-Chloro-2-methylphenoxy)acetic acid

Sorafenib Impurity 9

CAT No: CL-SFNB-36 CAS No: 3505-87-1 Mol Wt: 125.1 Mol F: C6H7NO2 Inv Status: Custom Synthesis

Chemical Name: 4-(Hydroxyamino)phenol

Sorafenib Impurity 10

CAT No: CL-SFNB-37 CAS No: 19448-54-5 Mol Wt: 253.6 Mol F: C9H7ClF3NO2 Inv Status: Custom Synthesis

Chemical Name: Methyl (4-chloro-3-(trifluoromethyl)phenyl)carbamate

Sorafenib Impurity 11

CAT No: CL-SFNB-38 CAS No: 156218-61-0 Mol Wt: 423.2 Mol F: C14H6Cl2F6O2S Inv Status: Custom Synthesis

Chemical Name: 4,4'-Sulfonylbis(1-chloro-2-(trifluoromethyl)benzene)

Sorafenib Impurity 12

CAT No: CL-SFNB-39 CAS No: 32333-53-2 Mol Wt: 279.1 Mol F: C7H3Cl2F3O2S Inv Status: Custom Synthesis

Chemical Name: 4-Chloro-3-(trifluoromethyl)benzene-1-sulfonyl chloride

Sorafenib Impurity 13

CAT No: CL-SFNB-40 CAS No: 50528-86-4 Mol Wt: 221.6 Mol F: C8H3ClF3NO Inv Status: Custom Synthesis

Chemical Name: 1-Chloro-2-isocyanato-4-(trifluoromethyl)benzene

Sorafenib Impurity 14

CAT No: CL-SFNB-41 CAS No: 329-01-1 Mol Wt: 187.1 Mol F: C8H4F3NO Inv Status: Custom Synthesis

Chemical Name: 1-Isocyanato-3-(trifluoromethyl)benzene

Sorafenib Impurity 15

CAT No: CL-SFNB-42 CAS No: 1065074-98-7 Mol Wt: 165.2 Mol F: C8H11N3O Inv Status: Custom Synthesis

Chemical Name: N-Methyl-4-(methylamino)picolinamide

Sorafenib Impurity 16

CAT No: CL-SFNB-43 CAS No: 757251-59-5 Mol Wt: 244.3 Mol F: C13H12N2O3 Inv Status: Custom Synthesis

Chemical Name: Methyl 4-(4-aminophenoxy)picolinate

Sorafenib Dimer Impurity 1

CAT No: CL-SFNB-44 CAS No: 2206827-18-9 Mol Wt: 555.6 Mol F: C28H25N7O6 Inv Status: Custom Synthesis

Chemical Name: 4,4'-((((Azanediylbis(carbonyl))bis(azanediyl))bis(4,1-phenylene))bis(oxy))bis(N-methylpicolinamide)

Sorafenib Impurity 18

CAT No: CL-SFNB-45 CAS No: 114780-06-2 Mol Wt: 184.6 Mol F: C8H9ClN2O Inv Status: Custom Synthesis

Chemical Name: 4-Chloro-N,N-dimethylpicolinamide

Sorafenib Impurity 19

CAT No: CL-SFNB-46 CAS No: 845306-05-0 Mol Wt: 184.6 Mol F: C8H9ClN2O Inv Status: Custom Synthesis

Chemical Name: 6-Chloro-N,N-dimethylpicolinamide

Sorafenib Impurity 20

CAT No: CL-SFNB-47 CAS No: 845306-04-9 Mol Wt: 170.6 Mol F: C7H7ClN2O Inv Status: Custom Synthesis

Chemical Name: 6-Chloro-N-methylpicolinamide

Sorafenib Impurity 21

CAT No: CL-SFNB-48 CAS No: 1858792-36-5 Mol Wt: 219.1 Mol F: C8H8Cl2N2O Inv Status: Custom Synthesis

Chemical Name: 4,6-Dichloro-N,N-dimethylpicolinamide

Sorafenib Impurity 22

CAT No: CL-SFNB-49 CAS No: 1379324-09-0 Mol Wt: 205 Mol F: C7H6Cl2N2O Inv Status: Custom Synthesis

Chemical Name: 4,6-Dichloro-N-methylpicolinamide

Sorafenib Impurity 23

CAT No: CL-SFNB-50 CAS No: 1850693-67-2 Mol Wt: 170.6 Mol F: C7H7ClN2O Inv Status: Custom Synthesis

Chemical Name: 3-Chloro-N-methylpicolinamide

Sorafenib Impurity 24

CAT No: CL-SFNB-51 CAS No: 1862431-14-8 Mol Wt: 184.6 Mol F: C8H9ClN2O Inv Status: Custom Synthesis

Chemical Name: 3-Chloro-N,N-dimethylpicolinamide

4-Chloro-N-methylpyridine-2-carboxamide

CAT No: CL-SFNB-52 CAS No: 220000-87-3 Mol Wt: 170.6 Mol F: C7H7ClN2O Inv Status: Custom Synthesis

Chemical Name: 4-Chloro-N-methylpicolinamide

6-Chloro-2-Picolinic Acid Methyl Ester

CAT No: CL-SFNB-53 CAS No: 6636-55-1 Mol Wt: 171.6 Mol F: C7H6ClNO2 Inv Status: Custom Synthesis

Chemical Name: Methyl 6-chloropicolinate

Phenyl Chloroformate

CAT No: CL-SFNB-54 CAS No: 1885-14-9 Mol Wt: 156.6 Mol F: C7H5ClO2 Inv Status: Custom Synthesis

Chemical Name: ?Phenyl chloroformate

p-Toluenesulfonic Acid Monohydrate

CAT No: CL-SFNB-55 CAS No: 6192-52-5 Mol Wt: 172.2 : 18.0 Mol F: C7H8O3S : H2O Inv Status: Custom Synthesis

Chemical Name: 4-Methylbenzenesulfonic acid hydrate

Sorafenib EP Impurity A

CAT No: CL-SFNB-56 CAS No: 284462-37-9 Mol Wt: 243.3 Mol F: C13H13N3O2 Inv Status: Custom Synthesis

Chemical Name: 4-(4-Aminophenoxy)-N-methylpyridine-2-carboxamide (as per EP); 4-(4-Aminophenoxy)-N-methylpicolinamide (as per USP)

Sorafenib Impurity 3

CAT No: CL-SFNB-57 CAS No: 1129683-83-5 Mol Wt: 330.7 Mol F: C14H10ClF3N2O2 Inv Status: Custom Synthesis

Chemical Name: 1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-hydroxyphenyl)urea

2-Chlorobenzotrifluoride

CAT No: CL-SFNB-58 CAS No: 88-16-4 Mol Wt: 180.6 Mol F: C7H4ClF3 Inv Status: Custom Synthesis

Chemical Name: 1-Chloro-2-(trifluoromethyl)benzene

Methyl 4,6-Dichloropicolinate

CAT No: CL-SFNB-59 CAS No: 98273-19-9 Mol Wt: 206 Mol F: C7H5Cl2NO2 Inv Status: Custom Synthesis

Chemical Name: Methyl 4,6-dichloropicolinate

Methyl 4-Chloropicolinate Hydrochloride

CAT No: CL-SFNB-60 CAS No: 176977-85-8 Mol Wt: 171.6 : 36.5 Mol F: C7H6ClNO2 : HCl Inv Status: Custom Synthesis

Chemical Name: Methyl 4-chloropicolinate hydrochloride

N-Methyl Picolinamide

CAT No: CL-SFNB-61 CAS No: 6144-78-1 Mol Wt: 136.2 Mol F: C7H8N2O Inv Status: Custom Synthesis

Chemical Name: N-Methyl-2-pyridinecarboxamide

Sorafenib Impurity 25

CAT No: CL-SFNB-62 CAS No: 98-56-6 Mol Wt: 180.6 Mol F: C7H4ClF3 Inv Status: Custom Synthesis

Chemical Name: 1-Chloro-4-(trifluoromethyl)benzene

Sorafenib Impurity 26

CAT No: CL-SFNB-63 CAS No: 343247-69-8 Mol Wt: 238.6 Mol F: C8H6ClF3N2O Inv Status: Custom Synthesis

Chemical Name: 1-(4-Chloro-3-(trifluoromethyl)phenyl)urea

Sorafenib Impurity 27

CAT No: CL-SFNB-64 CAS No: 777-44-6 Mol Wt: 244.6 Mol F: C7H4ClF3O2S Inv Status: Custom Synthesis

Chemical Name: 3-(Trifluoromethyl)benzenesulfonyl chloride

Sorafenib Impurity 28

CAT No: CL-SFNB-65 CAS No: 875167-01-4 Mol Wt: 279.1 Mol F: C7H3Cl2F3O2S Inv Status: Custom Synthesis

Chemical Name: 3-Chloro-5-(trifluoromethyl)benzenesulfonyl chloride

Sorafenib D3

CAT No: CL-SFNB-66 CAS No: 1130115-44-4 Mol Wt: 467.9 Mol F: C21H13D3ClF3N4O3 Inv Status: Custom Synthesis

Chemical Name: 4-(4-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)phenoxy)-N-(methyl-d3)picolinamide

Sorafenib 13CD3

CAT No: CL-SFNB-67 CAS No: 1210608-86-8 Mol Wt: 468.8 Mol F: C2013CH13D3ClF3N4O3 Inv Status: Custom Synthesis

Chemical Name: 4-(4-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)phenoxy)-N-(methyl-13C-d3)picolinamide

Sorafenib D4

CAT No: CL-SFNB-68 CAS No: 1207560-07-3 Mol Wt: 468.9 Mol F: C21H12D4ClF3N4O3 Inv Status: Custom Synthesis

Chemical Name: 4-(4-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)phenoxy-2,3,5,6-d4)-N-methylpicolinamide

Sorafenib N-Oxide 13CD3

CAT No: CL-SFNB-69 CAS No: NA Mol Wt: 484.8 Mol F: C2013CH13D3ClF3N4O4 Inv Status: Custom Synthesis

Chemical Name: 4-(4-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)phenoxy)-2-((methyl-13C-d3)carbamoyl)pyridine 1-oxide

Type:Impurity Reference Standard

Total Products: 68

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