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Cleanchem is a trusted provider of premium pharmaceutical reference materials, specializing in Palbociclib and its associated compounds. Our catalog includes pharmacopeial and non-pharmacopeial Palbociclib impurities, metabolites, nitrosamine derivatives (N-NO compounds), and stable isotope-labeled products. These reference standards play a critical role in pharmaceutical R&D, supporting activities such as product formulation, ANDA and DMF submissions, quality assurance, analytical method development, and stability assessments.
All Palbociclib-related substances undergo comprehensive characterization and are delivered with complete Certificates of Analysis and supporting analytical documentation to ensure regulatory adherence. Upon request, we can offer EP/USP traceable standards. Our products are routinely re-evaluated to maintain consistent quality and performance.

Palbociclib

CAT No: CL-PBC-01 CAS No: 571190-30-2 Mol Wt: 447.5 Mol F: C24H29N7O2 Inv Status: Custom Synthesis

Chemical Name: 6-Acetyl-8-cyclopentyl-5-methyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]pyrido[2,3-d]pyrimidin-7(8H)-one

Palbociclib Impurity 1

CAT No: CL-PBC-02 CAS No: 571190-22-2 Mol Wt: 405.5 Mol F: C22H27N7O Inv Status: Custom Synthesis

Chemical Name: 8-Cyclopentyl-5-methyl-2-[[(5-piperazin-1-ylpyridin-2-yl)]amino]-8H-pyrido[2,3-d]pyrimidin-7-one

Palbociclib Impurity 2

CAT No: CL-PBC-03 CAS No: 2204863-06-7 Mol Wt: 431.5 Mol F: C24H29N7O Inv Status: In Stock

Chemical Name: 8-Cyclopentyl-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-6-vinylpyrido[2,3-d]pyrimidin-7(8H)-one

Palbociclib Impurity 3

CAT No: CL-PBC-04 CAS No: 1651214-74-2 Mol Wt: 547.7 Mol F: C29H37N7O4 Inv Status: Custom Synthesis

Chemical Name: 1-?Piperazinecarboxylic acid, 4-?[6-?[(6-?acetyl-?8-?cyclopentyl-?7,?8-?dihydro-?5-?methyl-?7-?oxopyrido[2,?3-?d]?pyrimidin-?2-?yl)?amino]?-?3-?pyridinyl]?-?, 1,?1-?dimethylethyl ester

Palbociclib Impurity 4

CAT No: CL-PBC-05 CAS No: 1376615-91-6 Mol Wt: 449.6 Mol F: C24H31N7O2 Inv Status: Custom Synthesis

Chemical Name: Pyrido[2,?3-?d]?pyrimidin-?7(8H)?-?one, 8-?cyclopentyl-?6-?(1-?hydroxyethyl)?-?5-?methyl-?2-?[[5-?(1-?piperazinyl)?-?2-?pyridinyl]?amino]?-

Palbociclib Pyridine N-Oxide

CAT No: CL-PBC-06 CAS No: 2098673-40-4 Mol Wt: 463.5 Mol F: C24H29N7O3 Inv Status: Custom Synthesis

Chemical Name: 2-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)-5-(piperazin-1-yl)pyridine 1-oxide

Palbociclib Piperazine N-Oxide

CAT No: CL-PBC-07 CAS No: 2174002-29-8 Mol Wt: 463.5 Mol F: C24H29N7O3 Inv Status: Custom Synthesis

Chemical Name: 1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine 1-oxide

Palbociclib Impurity 7

CAT No: CL-PBC-08 CAS No: 827022-35-5 Mol Wt: 603.8 Mol F: C33H45N7O4 Inv Status: Custom Synthesis

Chemical Name: 1-?Piperazinecarboxylic acid, 4-?[6-?[[6-?[(1E)?-?2-?butoxyethenyl]?-?8-?cyclopentyl-?7,?8-?dihydro-?5-?methyl-?7-?oxopyrido[2,?3-?d]?pyrimidin-?2-?yl]?amino]?-?3-?pyridinyl]?-?, 1,?1-?dimethylethyl ester

Palbociclib Impurity 8

CAT No: CL-PBC-09 CAS No: 827022-31-1 Mol Wt: 575.7 Mol F: C31H41N7O4 Inv Status: Custom Synthesis

Chemical Name: Tert-butyl 4-(6-((8-cyclopentyl-6-(2-ethoxyvinyl)-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate

Palbociclib Impurity 9

CAT No: CL-PBC-10 CAS No: 2204368-66-9 Mol Wt: 447.5 : 5 Mol F: C24H29N7O2 Inv Status: Custom Synthesis

Chemical Name: 2-(8-cyclopentyl-5-methyl-7-oxo-2-((4-(piperazin-1-yl)phenyl)amino)-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl)acetaldehyde

Palbociclib Impurity 10

CAT No: CL-PBC-11 CAS No: 2206135-30-8 Mol Wt: 782 Mol F: C41H55N11O5 Inv Status: Custom Synthesis

Chemical Name: Di-tert-butyl 4,4'-(((8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2,6-diyl)bis(azanediyl))bis(pyridine-6,3-diyl))bis(piperazine-1-carboxylate)

Palbociclib Impurity 11

CAT No: CL-PBC-12 CAS No: 866084-31-3 Mol Wt: 603.8 Mol F: C33H45N7O4 Inv Status: Custom Synthesis

Chemical Name: Tert-butyl 4-(6-((6-(1-butoxyvinyl)-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate

Palbociclib Impurity 12

CAT No: CL-PBC-13 CAS No: 2204368-69-2 Mol Wt: 540.1 Mol F: C27H34ClN7O3 Inv Status: Custom Synthesis

Chemical Name: Tert-butyl 4-(6-((2-chloro-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl)amino)pyridin-3-yl)piperazine-1-carboxylate

Palbociclib Impurity 13

CAT No: CL-PBC-14 CAS No: 2204442-50-0 Mol Wt: 447.5 Mol F: C24H29N7O2 Inv Status: Custom Synthesis

Chemical Name: 2-acetyl-8-cyclopentyl-5-methyl-6-((5-(piperazin-1-yl)pyridin-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one

Palbociclib Impurity 14

CAT No: CL-PBC-15 CAS No: 2204863-10-3 Mol Wt: 527.6 Mol F: C24H29N7O5S Inv Status: Custom Synthesis

Chemical Name: 4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-sulfonic acid

Palbociclib Impurity 15

CAT No: CL-PBC-16 CAS No: 571189-65-6 Mol Wt: 505.6 Mol F: C27H35N7O3 Inv Status: Custom Synthesis

Chemical Name: Tert-butyl 4-(6-((8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate

Palbociclib Impurity 16

CAT No: CL-PBC-17 CAS No: 571189-64-5 Mol Wt: 286.3 Mol F: C15H18N4O2 Inv Status: Custom Synthesis

Chemical Name: 6-Acetyl-2-amino-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one

Palbociclib Impurity 17

CAT No: CL-PBC-18 CAS No: 851067-56-6 Mol Wt: 484.39 Mol F: C22H26BrN7O Inv Status: Custom Synthesis

Chemical Name: 6-Bromo-8-cyclopentyl-5-methyl-2-((5-(piperazine-1-yl)-pyridin-2-yl)amino)pyrido-[2,3-d]pyrimidin-7-(8H)-one

Palbociclib Impurity 18

CAT No: CL-PBC-19 CAS No: 2206827-36-1 Mol Wt: 589.7 Mol F: C32H43N7O4 Inv Status: Custom Synthesis

Chemical Name: Tert-butyl-4-(6-6-(1-butoxylvinyl)-8-cyclopenyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-ylamino)pyridin-3-yl)piperazine-1-carboxylate

Palbociclib Impurity 19

CAT No: CL-PBC-20 CAS No: 2205035-04-5 Mol Wt: 447.5 Mol F: C24H29N7O2 Inv Status: Custom Synthesis

Chemical Name: 6-Acetyl-8-cyclopentyl-5-methyl-2-((3-(piperazin- l-yl)pyridin-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one

Palbociclib Impurity 20

CAT No: CL-PBC-21 CAS No: 2459303-21-8 Mol Wt: 531.7 Mol F: C28H37N9O2 Inv Status: Custom Synthesis

Chemical Name: 6-Acetyl-8-cyclopentyl-2-((3,6-di(piperazin-l-yl)pyridin-2-yl)amino)-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one

Palbociclib Impurity 21

CAT No: CL-PBC-22 CAS No: 2458234-37-0 Mol Wt: 581.7 Mol F: C31H39N11O Inv Status: Custom Synthesis

Chemical Name: 8-Cyclopentyl-5-methyl-2,6-bis((5-(piperazin-1-yl)pyridin-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one

Palbociclib Dimer Impurity

CAT No: CL-PBC-23 CAS No: 2458234-34-7 Mol Wt: 968.8 Mol F: C44H52Br2N14O2 Inv Status: Custom Synthesis

Chemical Name: 6-Bromo-5-((6-bromo-8-cyclopentyl-7-oxo-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-1,4,7,8-tetrahydropyrido[2,3-d]pyrimidin-4-yl)methyl)-8-cyclopentyl-4-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one

N-Boc Protected Palbociclib Dimer

CAT No: CL-PBC-24 CAS No: NA Mol Wt: 1169.1 Mol F: C54H68Br2N14O6 Inv Status: Custom Synthesis

Chemical Name: Tert-butyl 4-(6-((6-bromo-4-((6-bromo-2-((5-(4-(tert-butoxycarbonyl)piperazin-1-yl)pyridin-2-yl)amino)-8-cyclopentyl-4-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-5-yl)methyl)-8-cyclopentyl-7-oxo-1,4,7,8-tetrahydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate

Palbociclib Impurity 22

CAT No: CL-PBC-25 CAS No: 1922954-32-2 Mol Wt: 324.2 Mol F: C13H14BrN3O2 Inv Status: Custom Synthesis

Chemical Name: 6-Bromo-8-cyclopentyl-2-hydroxy-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one

Palbociclib Impurity C

CAT No: CL-PBC-26 CAS No: 2624141-94-0 Mol Wt: 461.6 Mol F: C25H31N7O2 Inv Status: Custom Synthesis

Chemical Name: 6-Acetyl-8-cyclohexyl-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)pyrido[2,3-d]pyrimidin-7-one

Palbociclib Impurity 23

CAT No: CL-PBC-27 CAS No: 2270982-31-3 Mol Wt: 503.7 Mol F: C28H37N7O2 Inv Status: Custom Synthesis

Chemical Name: 6-(1-Butoxyvinyl)-8-cyclopentyl-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one

Palbociclib Lactose Adduct Impurity

CAT No: CL-PBC-28 CAS No: NA Mol Wt: 771.8 Mol F: C36H49N7O12 Inv Status: Custom Synthesis

Chemical Name: 6-Acetyl-8-cyclopentyl-2-((5-(4-((3R,4R,5S,6R)-3,4-dihydroxy-6-(hydroxymethyl)-5-(((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)piperazin-1-yl)pyridin-2-yl)amino)-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one

Palbociclib Millard Reaction Impurity

CAT No: CL-PBC-29 CAS No: NA Mol Wt: 771.8 Mol F: C36H49N7O12 Inv Status: Custom Synthesis

Chemical Name: 6-Acetyl-8-cyclopentyl-5-methyl-2-((5-(4-((3S,4R,5R)-3,5,6-trihydroxy-2-oxo-4-(((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexyl)piperazin-1-yl)pyridin-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one

Palbociclib N-Formyl Impurity

CAT No: CL-PBC-30 CAS No: 2174002-16-3 Mol Wt: 475.6 Mol F: C25H29N7O3 Inv Status: Custom Synthesis

Chemical Name: 4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carbaldehyde

Palbociclib 4-Piperazin-N-Oxide

CAT No: CL-PBC-31 CAS No: 2231085-26-8 Mol Wt: 463.5 Mol F: C24H29N7O3 Inv Status: Custom Synthesis

Chemical Name: 4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine 1-oxide

Palbociclib Oxidation Impurity

CAT No: CL-PBC-32 CAS No: 2363160-84-1 Mol Wt: 436.5 Mol F: C22H24N6O4 Inv Status: Custom Synthesis

Chemical Name: (6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)glycine

Maltol

CAT No: CL-PBC-33 CAS No: 118-71-8 Mol Wt: 126.1 Mol F: C6H6O3 Inv Status: Custom Synthesis

Chemical Name: 3-Hydroxy-2-methyl-4H-pyran-4-one

Palbociclib Impurity 28

CAT No: CL-PBC-34 CAS No: 28564-83-2 Mol Wt: 144.13 Mol F: C6H8O4 Inv Status: Custom Synthesis

Chemical Name: 3,5-Dihydroxy-6-methyl-2,3-dihydro-4H-pyran-4-one

Palbociclib Impurity 29

CAT No: CL-PBC-35 CAS No: 571191-15-6 Mol Wt: 421.5 Mol F: C22H27N7O2 Inv Status: Custom Synthesis

Chemical Name: 6-acetyl-2-((5-((2-aminoethyl)amino)pyridin-2-yl)amino)-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one

Palbociclib Impurity 30

CAT No: CL-PBC-36 CAS No: 2324831-15-2 Mol Wt: 421.5 Mol F: C13H12Br2ClN3O Inv Status: Custom Synthesis

Chemical Name: 6-bromo-5-(bromomethyl)-2-chloro-8-cyclopentylpyrido[2,3-d]pyrimidin-7(8H)-one

Palbociclib N-BOC 6-Bromo Analog

CAT No: CL-PBC-37 CAS No: 571188-82-4 Mol Wt: 584.5 Mol F: C27H34BrN7O3 Inv Status: In Stock

Chemical Name: Tert-butyl 4-(6-((6-bromo-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate

Palbociclib Impurity 35

CAT No: CL-PBC-38 CAS No: 571188-59-5 Mol Wt: 278.35 Mol F: C14H22N4O2 Inv Status: In Stock

Chemical Name: 1-Boc-4-(6-aminopyridin-3-yl)piperazine

Palbociclib Impurity 63

CAT No: CL-PBC-39 CAS No: 39856-50-3 Mol Wt: 202.99 Mol F: C5H3BrN2O2 Inv Status: In Stock

Chemical Name: 5-Bromo-2-nitropyridine

Palbociclib Impurity 56

CAT No: CL-PBC-40 CAS No: 571189-16-7 Mol Wt: 264.32 Mol F: C13H20N402 Inv Status: In Stock

Chemical Name: Tert-butyl 4-(6-nitropyridin-3-yl)piperazine

Type:Impurity Reference Standard

Total Products: 40

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