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Cleanchem is a trusted provider of premium pharmaceutical reference materials, specializing in Hydrochlorothiazide and its associated compounds. Our catalog includes pharmacopeial and non-pharmacopeial Hydrochlorothiazide impurities, metabolites, nitrosamine derivatives (N-NO compounds), and stable isotope-labeled products. These reference standards play a critical role in pharmaceutical R&D, supporting activities such as product formulation, ANDA and DMF submissions, quality assurance, analytical method development, and stability assessments.
All Hydrochlorothiazide-related substances undergo comprehensive characterization and are delivered with complete Certificates of Analysis and supporting analytical documentation to ensure regulatory adherence. Upon request, we can offer EP/USP traceable standards. Our products are routinely re-evaluated to maintain consistent quality and performance.

Hydrochlorothiazide

CAT No: CL-HLZ-01 CAS No: 58-93-5 Mol Wt: 297.7 Mol F: C7H8ClN3O4S2 Inv Status: Custom Synthesis

Chemical Name: 6-Chloro-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide 1,1-dioxide

Hydrochlorothiazide EP Impurity A

CAT No: CL-HLZ-02 CAS No: 58-94-6 Mol Wt: 295.7 Mol F: C7H6ClN3O4S2 Inv Status: In Stock

Chemical Name: 6-Chloro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide

Hydrochlorothiazide EP Impurity B

CAT No: CL-HLZ-03 CAS No: 121-30-2 Mol Wt: 285.7 Mol F: C6H8ClN3O4S2 Inv Status: In Stock

Chemical Name: 4-Amino-6-chlorobenzene-1,3-disulfonamide

Hydrochlorothiazide EP Impurity C

CAT No: CL-HLZ-04 CAS No: 402824-96-8 Mol Wt: 607.5 Mol F: C15H16Cl2N6O8S4 Inv Status: Custom Synthesis

Chemical Name: 6-Chloro-N-[(6-chloro-7-sulfamoyl-2,3-dihydro-4H-1,2,4-benzothiadiazin-4-yl 1,1-dioxide)methyl]-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide

Hydrochlorothiazide 5-Chloro Impurity

CAT No: CL-HLZ-05 CAS No: 5233-42-1 Mol Wt: 332.2 Mol F: C7H7Cl2N3O4S2 Inv Status: Custom Synthesis

Chemical Name: 5,6-Dichloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide

Hydrochlorothiazide 13C6

CAT No: CL-HLZ-06 CAS No: 1261396-79-5 Mol Wt: 303.7 Mol F: C13C6H8ClN3O4S2 Inv Status: Custom Synthesis

Chemical Name: 6-Chloro-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide-4a,5,6,7,8,8a-13C6 1,1-dioxide

Hydrochlorothiazide Hydroxy Impurity

CAT No: CL-HLZ-07 CAS No: 17277-91-7 Mol Wt: 286.7 Mol F: C6H7ClN2O5S2 Inv Status: Custom Synthesis

Chemical Name: 4-Amino-2-chloro-5-sulfamoylbenzenesulfonic acid

Hydrochlorothiazide Impurity 1

CAT No: CL-HLZ-08 CAS No: NA Mol Wt: 286.7 Mol F: C6H7ClN2O5S2 Inv Status: Custom Synthesis

Chemical Name: 2-Amino-4-chloro-5-sulfamoylbenzenesulfonic acid

Hydrochlorothiazide Impurity 2

CAT No: CL-HLZ-09 CAS No: 1214-64-8 Mol Wt: 296.7 Mol F: C6H5ClN4O4S2 Inv Status: Custom Synthesis

Chemical Name: 6-Chloro-2H-benzo[e][1,2,3,4]thiatriazine-7-sulfonamide 1,1-dioxide

Hydrochlorothiazide Impurity 3

CAT No: CL-HLZ-10 CAS No: 5790-69-2 Mol Wt: 206.6 Mol F: C6H7ClN2O2S Inv Status: Custom Synthesis

Chemical Name: 2-Amino-5-chlorobenzenesulfonamide

Hydrochlorothiazide Impurity 4

CAT No: CL-HLZ-11 CAS No: 957785-35-2 Mol Wt: 236.6 Mol F: C6H5ClN2O4S Inv Status: Custom Synthesis

Chemical Name: 3-chloro-5-nitrobenzenesulfonamide

Hydrochlorothiazide Impurity 5

CAT No: CL-HLZ-12 CAS No: 69031-67-0 Mol Wt: 281.3 Mol F: C6H7N3O6S2 Inv Status: Custom Synthesis

Chemical Name: 5-Nitrobenzene-1,3-disulfonamide

Hydrochlorothiazide Impurity 6

CAT No: CL-HLZ-13 CAS No: NA Mol Wt: 315.7 Mol F: C6H6ClN3O6S2 Inv Status: Custom Synthesis

Chemical Name: 2-Chloro-5-nitrobenzene-1,3-disulfonamide

Hydrochlorothiazide Impurity 7

CAT No: CL-HLZ-14 CAS No: 19477-32-8 Mol Wt: 218.7 Mol F: C7H7ClN2O2S Inv Status: Custom Synthesis

Chemical Name: 6-Chloro-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine 1,1-dioxide

Hydrochlorothiazide Impurity 8

CAT No: CL-HLZ-15 CAS No: 1083-36-9 Mol Wt: 285.7 Mol F: C6H8ClN3O4S2 Inv Status: Custom Synthesis

Chemical Name: 4-Amino-5-chlorobenzene-1,3-disulfonamide

Hydrochlorothiazide Impurity 9

CAT No: CL-HLZ-16 CAS No: 40642-90-8 Mol Wt: 251.3 Mol F: C6H9N3O4S2 Inv Status: Custom Synthesis

Chemical Name: 4-Aminobenzene-1,3-disulfonamide

Hydrochlorothiazide Impurity 10

CAT No: CL-HLZ-17 CAS No: 5250-72-6 Mol Wt: 320.2 Mol F: C6H7Cl2N3O4S2 Inv Status: Custom Synthesis

Chemical Name: 4-Amino-5,6-dichlorobenzene-1,3-disulfonamide

Hydrochlorothiazide Impurity 11

CAT No: CL-HLZ-18 CAS No: 856302-12-0 Mol Wt: 297.7 Mol F: C7H8ClN3O4S2 Inv Status: Custom Synthesis

Chemical Name: 5-Chloro-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide 1,1-dioxide

Hydrochlorothiazide Impurity 12

CAT No: CL-HLZ-19 CAS No: 23141-82-4 Mol Wt: 263.3 Mol F: C7H9N3O4S2 Inv Status: Custom Synthesis

Chemical Name: 3,4-Dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide 1,1-dioxide

Hydrochlorothiazide Impurity 13

CAT No: CL-HLZ-20 CAS No: 4140-83-4 Mol Wt: 206.6 Mol F: C6H7ClN2O2S Inv Status: Custom Synthesis

Chemical Name: 2-Amino-4-chlorobenzenesulfonamide

Hydrochlorothiazide Impurity 14

CAT No: CL-HLZ-21 CAS No: 1954-94-5 Mol Wt: 206.6 Mol F: C6H7ClN2O2S Inv Status: Custom Synthesis

Chemical Name: 4-Amino-2-chlorobenzenesulfonamide

Hydrochlorothiazide Impurity 15

CAT No: CL-HLZ-22 CAS No: 99418-26-5 Mol Wt: 287.7 Mol F: C6H6ClNO6S2 Inv Status: In Stock

Chemical Name: 4-Amino-6-chlorobenzene-1,3-disulfonic acid

Hydrochlorothiazide Impurity 16

CAT No: CL-HLZ-23 CAS No: 13852-81-8 Mol Wt: 236.6 Mol F: C6H5ClN2O4S Inv Status: Custom Synthesis

Chemical Name: 4-Chloro-2-nitrobenzenesulfonamide

Hydrochlorothiazide Impurity 17

CAT No: CL-HLZ-24 CAS No: 1216599-78-8 Mol Wt: 327.8 Mol F: C8H10ClN3O5S2 Inv Status: Custom Synthesis

Chemical Name: 6-Chloro-4-(hydroxymethyl)-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide 1,1-dioxide

Hydrochlorothiazide Impurity 18

CAT No: CL-HLZ-25 CAS No: Mol Wt: 298.7 Mol F: C7H7ClN2O5S2 Inv Status: Custom Synthesis

Chemical Name: 6-Chloro-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonic acid 1,1-dioxide

Hydrochlorothiazide Impurity 19

CAT No: CL-HLZ-26 CAS No: 1261761-91-4 Mol Wt: 236.6 Mol F: C6H5ClN2O4S Inv Status: Custom Synthesis

Chemical Name: 2-Chloro-3-nitrobenzenesulfonamide

Hydrochlorothiazide Impurity 20

CAT No: CL-HLZ-27 CAS No: 31150-99-9 Mol Wt: 236.6 Mol F: C6H5ClN2O4S Inv Status: Custom Synthesis

Chemical Name: 2-Chloro-4-nitrobenzenesulfonamide

Hydrochlorothiazide D2

CAT No: CL-HLZ-28 CAS No: 1219798-89-6 Mol Wt: 299.7 Mol F: C7H6D2ClN3O4S2 Inv Status: Custom Synthesis

Chemical Name: 6-Chloro-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide-3,3-d2 1,1-dioxide

Hydrochlorothiazide-13C,15N2,d2

CAT No: CL-HLZ-29 CAS No: NA Mol Wt: 302.7 Mol F: C613CH6D2ClN15N2O4S2 Inv Status: Custom Synthesis

Chemical Name: 6-Chloro-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide-3-13C-3,3-d2-2-15N-15N 1,1-dioxide

Hydrochlorothiazide Impurity 32

CAT No: CL-HLZ-30 CAS No: 97-09-6 Mol Wt: 236.6 Mol F: C6H5ClN2O4S Inv Status: Custom Synthesis

Chemical Name: 4-Chloro-3-nitrobenzenesulfonamide

Hydrochlorothiazide Impurity 21

CAT No: CL-HLZ-31 CAS No: 360-81-6 Mol Wt: 196.2 Mol F: C8H8N2O2S Inv Status: Custom Synthesis

Chemical Name: 3-Methyl-4H-benzo[e][1,2,4]thiadiazine 1,1-dioxide

Hydrochlorothiazide Impurity 22

CAT No: CL-HLZ-32 CAS No: 100960-19-8 Mol Wt: 297.7 Mol F: C7H8ClN3O4S2 Inv Status: Custom Synthesis

Chemical Name: 7-Chloro-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-5-sulfonamide 1,1-dioxide

Hydrochlorothiazide Impurity 23

CAT No: CL-HLZ-33 CAS No: 75304-18-6 Mol Wt: 214.2 Mol F: C8H10N2O3S Inv Status: Custom Synthesis

Chemical Name: N-((2-Aminophenyl)sulfonyl)acetamide

Hydrochlorothiazide Impurity 24

CAT No: CL-HLZ-34 CAS No: 364-96-5 Mol Wt: 265.1 Mol F: C8H6Cl2N2O2S Inv Status: Custom Synthesis

Chemical Name: 6,7-Dichloro-3-methyl-4H-benzo[e][1,2,4]thiadiazine 1,1-dioxide

Hydrochlorothiazide Impurity 25

CAT No: CL-HLZ-35 CAS No: 5250-71-5 Mol Wt: 359 Mol F: C6H3Cl4NO4S2 Inv Status: Custom Synthesis

Chemical Name: 4-Amino-5,6-dichlorobenzene-1,3-disulfonyl dichloride

Hydrochlorothiazide Impurity 26

CAT No: CL-HLZ-36 CAS No: 2089381-36-0 Mol Wt: 343.8 Mol F: C10H14ClNO6S2 Inv Status: Custom Synthesis

Chemical Name: Diethyl 4-amino-6-chlorobenzene-1,3-disulfonate

Hydrochlorothiazide Impurity 27

CAT No: CL-HLZ-37 CAS No: 23141-75-5 Mol Wt: 261.3 Mol F: C7H7N3O4S2 Inv Status: Custom Synthesis

Chemical Name: 4H-Benzo[e][1,2,4]thiadiazine-7-sulfonamide 1,1-dioxide

Hydrochlorothiazide Impurity 28

CAT No: CL-HLZ-38 CAS No: 89813-56-9 Mol Wt: 311.7 Mol F: C7H6ClN3O5S2 Inv Status: Custom Synthesis

Chemical Name: 6-Chloro-3-oxo-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide 1,1-dioxide

Hydrochlorothiazide Impurity 29

CAT No: CL-HLZ-39 CAS No: 1668-63-9 Mol Wt: 313.8 Mol F: C8H12ClN3O4S2 Inv Status: Custom Synthesis

Chemical Name: 6-Amino-4-chloro-N1-ethylbenzene-1,3-disulfonamide

Hydrochlorothiazide Impurity 30

CAT No: CL-HLZ-40 CAS No: 90794-87-9 Mol Wt: 290.7 Mol F: C10H11ClN2O4S Inv Status: Custom Synthesis

Chemical Name: N-((2-Acetamido-5-chlorophenyl)sulfonyl)acetamide

Hydrochlorothiazide Impurity 31

CAT No: CL-HLZ-41 CAS No: 22503-74-8 Mol Wt: 218.7 Mol F: C7H7ClN2O2S Inv Status: Custom Synthesis

Chemical Name: 7-Chloro-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine 1,1-dioxide

Hydrochlorothiazide Impurity 33

CAT No: CL-HLZ-42 CAS No: 19185-77-4 Mol Wt: 248.7 Mol F: C8H9ClN2O3S Inv Status: Custom Synthesis

Chemical Name: N-(4-Chloro-2-sulfamoylphenyl)acetamide

Type:Impurity Reference Standard

Total Products: 42

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