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Gefapixant is a selective P2X3 receptor antagonist that is being investigated for the treatment of chronic cough. It works by blocking the action of the P2X3 receptor, which plays a role in the sensory pathways of cough reflex. The drug has shown promise in clinical trials for reducing cough frequency and severity.
Cleanchem is a trusted provider of premium pharmaceutical reference materials, specializing in Gefapixant and its associated compounds. Our catalog includes pharmacopeial and non-pharmacopeial Gefapixant impurities, metabolites, nitrosamine derivatives (N-NO compounds), and stable isotope-labeled products. These reference standards play a critical role in pharmaceutical R&D, supporting activities such as product formulation, ANDA and DMF submissions, quality assurance, analytical method development, and stability assessments.
All Gefapixant-related substances undergo comprehensive characterization and are delivered with complete Certificates of Analysis and supporting analytical documentation to ensure regulatory adherence. Upon request, we can offer EP/USP traceable standards. Our products are routinely re-evaluated to maintain consistent quality and performance.

Gefapixant
CAT No: CL-GFPX-001 CAS No: 1015787-98-0 Mol Wt: 353.4 Mol F: C14H19N5O4S Inv Status: Custom Synthesis
Chemical Name: 5-((2,4-Diaminopyrimidin-5-yl)oxy)-4-isopropyl-2-methoxybenzenesulfonamide
Gefapixant Impurity 1
CAT No: CL-GFPX-002 CAS No: 13522-86-6 Mol Wt: 166.2 Mol F: C10H14O2 Inv Status: Custom Synthesis
Chemical Name: 2-Isopropyl-4-methoxyphenol
Gefapixant Impurity 2
CAT No: CL-GFPX-003 CAS No: 927872-64-8 Mol Wt: 205.3 Mol F: C12H15NO2 Inv Status: Custom Synthesis
Chemical Name: 2-(2-Isopropyl-4-methoxyphenoxy)acetonitrile
Gefapixant Impurity 3
CAT No: CL-GFPX-004 CAS No: 1015787-97-9 Mol Wt: 354.4 Mol F: C14H18N4O5S Inv Status: Custom Synthesis
Chemical Name: 5-((2,Diaminopyrimidin-5-yl)oxy)-4-isopropyl-2-methoxybenzenesulfonic acid
Gefapixant Impurity 4
CAT No: CL-GFPX-005 CAS No: 1145715-92-9 Mol Wt: 308.8 Mol F: C14H17ClN4O2 Inv Status: Custom Synthesis
Chemical Name: 5-(5-Chloro-2-isopropyl-4-methoxyphenoxy)pyrimidine-2,4-diamine
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