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Digoxin is a cardiac glycoside used in heart failure and atrial fibrillation. It increases cardiac contractility and slows AV nodal conduction. Its narrow therapeutic index requires careful monitoring of blood levels.
Cleanchem is a trusted provider of premium pharmaceutical reference materials, specializing in Digoxin and its associated compounds. Our catalog includes pharmacopeial and non-pharmacopeial Digoxin impurities, metabolites, nitrosamine derivatives (N-NO compounds), and stable isotope-labeled products. These reference standards play a critical role in pharmaceutical R&D, supporting activities such as product formulation, ANDA and DMF submissions, quality assurance, analytical method development, and stability assessments.
All Digoxin-related substances undergo comprehensive characterization and are delivered with complete Certificates of Analysis and supporting analytical documentation to ensure regulatory adherence. Upon request, we can offer EP/USP traceable standards. Our products are routinely re-evaluated to maintain consistent quality and performance.

Digoxin
CAT No: CL-DGX-01 CAS No: 20830-75-5 Mol Wt: 780.9 Mol F: C41H64O14 Inv Status: Custom Synthesis
Chemical Name: 3?-[(2,6-Dideoxy-?-D-ribo-hexopyranosyl-(1?4)-2,6-dideoxy-?-D-ribo-hexopyranosyl-(1?4)-2,6-dideoxy-?-D-ribo-hexopyranosyl)oxy]-12?,14-dihydroxy-5?-card-20(22)-enolide.
Digoxin EP Impurity A
CAT No: CL-DGX-02 CAS No: 71-63-6 Mol Wt: 765 Mol F: C41H64O13 Inv Status: Custom Synthesis
Chemical Name: 4-((3S,5R,8R,9S,10S,13R,14S,17R)-3-(((2R,4S,5S,6R)-5-(((2S,4S,5S,6R)-5-(((2S,4S,5S,6R)-4,5-dihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-14-hydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)furan-2(5H)-one
Digoxin EP Impurity B
CAT No: CL-DGX-03 CAS No: 4562-36-1 Mol Wt: 780.9 Mol F: C41H64O14 Inv Status: Custom Synthesis
Chemical Name: 4-((3S,5R,8R,9S,10S,13R,14S,16S,17R)-3-(((2R,4S,5S,6R)-5-(((2S,4S,5S,6R)-5-(((2S,4S,5S,6R)-4,5-dihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-14,16-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)furan-2(5H)-one
Digoxin EP Impurity C
CAT No: CL-DGX-04 CAS No: 1672-46-4 Mol Wt: 390.5 Mol F: C23H34O5 Inv Status: Custom Synthesis
Chemical Name: 4-((3S,5R,8R,9S,10S,12R,13S,14S,17R)-3,12,14-trihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)furan-2(5H)-one
Digoxin EP Impurity D
CAT No: CL-DGX-05 CAS No: 5352-63-6 Mol Wt: 520.7 Mol F: C29H44O8 Inv Status: Custom Synthesis
Chemical Name: 4-((3S,5R,8R,9S,10S,12R,13S,14S,17R)-3-(((2R,4S,5S,6R)-4,5-dihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-12,14-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)furan-2(5H)-one
Digoxin EP Impurity E
CAT No: CL-DGX-06 CAS No: 52589-12-5 Mol Wt: 798.9 Mol F: C40H62O16 Inv Status: Custom Synthesis
Chemical Name: 4-((3S,5R,8R,9S,10S,12R,13S,14S,16S,17R)-3-(((2R,4S,5R,6R)-5-(((2S,4S,5S,6R)-5-(((2S,4S,5S,6R)-4,5-dihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4-hydroxy-6-methyl-1,3-dioxan-2-yl)oxy)-12,14,16-trihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)furan-2(5H)-one
Digoxin EP Impurity F
CAT No: CL-DGX-07 CAS No: (5297-05-2) Mol Wt: 650.8 Mol F: C35H54O11 Inv Status: Custom Synthesis
Chemical Name: 4-((3S,5R,8R,9S,10S,12R,13S,14S,17R)-3-(((2R,4S,5S,6R)-5-(((2S,4S,5S,6R)-4,5-dihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-12,14-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)furan-2(5H)-one
Digoxin EP Impurity G
CAT No: CL-DGX-08 CAS No: 55576-67-5 Mol Wt: 823 Mol F: C43H66O15 Inv Status: Custom Synthesis
Chemical Name: (2R,3R,4S,6S)-6-(((2R,3S,4S,6S)-6-(((2R,3S,4S,6R)-6-(((3S,5R,8R,9S,10S,12R,13S,14S,17R)-12,14-dihydroxy-10,13-dimethyl-17-(5-oxo-2,5-dihydrofuran-3-yl)hexadecahydro-1H-cyclopenta[a]phenanthren-3-yl)oxy)-4-hydroxy-2-methyltetrahydro-2H-pyran-3-yl)oxy)-4-hydroxy-2-methyltetrahydro-2H-pyran-3-yl)oxy)-3-hydroxy-2-methyltetrahydro-2H-pyran-4-yl acetate
Digoxin EP Impurity H
CAT No: CL-DGX-09 CAS No: 17575-22-3 Mol Wt: 985.1 Mol F: C49H76O20 Inv Status: Custom Synthesis
Chemical Name: 3?[(?D-glucopyranosyl-(1?4)-3-O-acetyl-2,6-dideoxy-?D-ribo-hexopyranosyl-(1?4)-2,6-dideoxy-?D-ribo-hexopyranosyl-(1?4)-2,6-dideoxy-?D-ribo-hexopyranosyl)oxy]-12?14-dihydroxy-5?card-20(22)-enolide
Digoxin EP Impurity I
CAT No: CL-DGX-10 CAS No: 5511-98-8 Mol Wt: 823 Mol F: C43H66O15 Inv Status: Custom Synthesis
Chemical Name: (2R,3R,4S,6S)-6-(((2R,3S,4S,6S)-6-(((2R,3S,4S,6R)-6-(((3S,5R,8R,9S,10S,12R,13S,14S,17R)-12,14-dihydroxy-10,13-dimethyl-17-(5-oxo-2,5-dihydrofuran-3-yl)hexadecahydro-1H-cyclopenta[a]phenanthren-3-yl)oxy)-4-hydroxy-2-methyltetrahydro-2H-pyran-3-yl)oxy)-4-hydroxy-2-methyltetrahydro-2H-pyran-3-yl)oxy)-3-hydroxy-2-methyltetrahydro-2H-pyran-4-yl acetate
Digoxin EP Impurity J
CAT No: CL-DGX-11 CAS No: 5355-48-6 Mol Wt: 823 Mol F: C43H66O15 Inv Status: Custom Synthesis
Chemical Name: (2R,3S,4S,6S)-6-(((2R,3S,4S,6S)-6-(((2R,3S,4S,6R)-6-(((3S,5R,8R,9S,10S,12R,13S,14S,17R)-12,14-dihydroxy-10,13-dimethyl-17-(5-oxo-2,5-dihydrofuran-3-yl)hexadecahydro-1H-cyclopenta[a]phenanthren-3-yl)oxy)-4-hydroxy-2-methyltetrahydro-2H-pyran-3-yl)oxy)-4-hydroxy-2-methyltetrahydro-2H-pyran-3-yl)oxy)-4-hydroxy-2-methyltetrahydro-2H-pyran-3-yl acetate
Digoxin D3
CAT No: CL-DGX-12 CAS No: 127299-95-0 Mol Wt: 784 Mol F: C41H61D3O14 Inv Status: Custom Synthesis
Chemical Name: 4-((3S,5R,8R,9S,10S,12R,13S,14S,17R)-3-(((2R,4S,5S,6R)-5-(((2S,4S,5S,6R)-5-(((2S,4S,5S,6R)-4,5-dihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-12,14-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)furan-2(5H)-one-3,5,5-d3
Digoxin EP Impurity K
CAT No: CL-DGX-13 CAS No: NA Mol Wt: 911.1 Mol F: C47H74O17 Inv Status: Custom Synthesis
Chemical Name: 3beta-[(2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1?4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1?4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1?4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl)oxy]-12beta,14-dihydroxy-5beta-card-20(22)-enolide
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