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Diflucortolone valerate is a potent corticosteroid used topically to treat inflammatory skin conditions like eczema and psoriasis. It reduces inflammation and itching. It must be used cautiously to avoid skin atrophy.
Cleanchem is a trusted provider of premium pharmaceutical reference materials, specializing in Diflucortolone Valerate and its associated compounds. Our catalog includes pharmacopeial and non-pharmacopeial Diflucortolone Valerate impurities, metabolites, nitrosamine derivatives (N-NO compounds), and stable isotope-labeled products. These reference standards play a critical role in pharmaceutical R&D, supporting activities such as product formulation, ANDA and DMF submissions, quality assurance, analytical method development, and stability assessments.
All Diflucortolone Valerate-related substances undergo comprehensive characterization and are delivered with complete Certificates of Analysis and supporting analytical documentation to ensure regulatory adherence. Upon request, we can offer EP/USP traceable standards. Our products are routinely re-evaluated to maintain consistent quality and performance.

Diflucortolone Valerate Impurity 1
CAT No: CL-DFTO-01 CAS No: (2607-06-9) Mol Wt: 394.45 Mol F: C22H28F2O4 Inv Status: Custom Synthesis
Chemical Name: (6S, 8S, 9R, 10S, 11S, 13S, 14S, 16R, 17S)-6, 9-difluoro-11-hydroxy-17-(2-hydroxyacetyl)-10, 13, 16-trimethyl-6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one
Diflucortolone Valerate Impurity 2
CAT No: CL-DFTO-02 CAS No: 2541-37-9 Mol Wt: 436.49 Mol F: C24H30F2O5 Inv Status: Custom Synthesis
Chemical Name: 2-((6S, 8S, 9R, 10S, 11S, 13S, 14S, 16R, 17S)-6, 9-difluoro-11-hydroxy-10, 13, 16-trimethyl-3-oxo-6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate
Diflucortolone Valerate Impurity 3
CAT No: CL-DFTO-03 CAS No: NA Mol Wt: 495.03 Mol F:  C27H36ClFO5 Inv Status: Custom Synthesis
Chemical Name: 2-((6S,8S,9R,10S,11S,13S,16R,17S)-6-chloro-9-fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl pentanoate, 6a-chloro analog
Diflucortolone Valerate Impurity 4
CAT No: CL-DFTO-04 CAS No: NA Mol Wt: 494.6 Mol F: C27H36F2O6 Inv Status: Custom Synthesis
Chemical Name: 2-((6S,8S,9R,10S,11S,13S,16R,17R)-6,9-difluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl pentanoate, Flumethasone valerate
Diflucortolone Valerate Impurity 5
CAT No: CL-DFTO-05 CAS No: 61633-73-6 Mol Wt: 464.5 Mol F: C26H34F2O5 Inv Status: Custom Synthesis
Chemical Name: 2-((6S,8S,9R,10S,11S,13S,14S,16R,17S)-6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl butyrate
Diflucortolone Valerate Impurity 6
CAT No: CL-DFTO-06 CAS No: NA Mol Wt: 495.02 Mol F: C27H36ClFO5 Inv Status: Custom Synthesis
Chemical Name: 2-((6S, 8S, 9R, 10S, 11S, 13S, 14S, 16R, 17S)-9-chloro-6-fluoro-11-hydroxy-10, 13, 16-trimethyl-3-oxo-6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl pentanoate
Diflucortolone Valerate Impurity 7
CAT No: CL-DFTO-07 CAS No: 65535-29-7 Mol Wt: 458.25 Mol F: C27H35FO5 Inv Status: Custom Synthesis
Chemical Name: Diflucortolone Valerate Impurity 7
Diflucortolone Valerate Impurity 8
CAT No: CL-DFTO-08 CAS No: NA Mol Wt: 478.6 Mol F: C27H36F2O5 Inv Status: Custom Synthesis
Chemical Name: 2-((6S,8S,9R,10S,11S,13S,16R,17S)-6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl pentanoate, De-6-fluoro valerate
Diflucortolone Valerate Impurity 9
CAT No: CL-DFTO-09 CAS No: NA Mol Wt: 480.6 Mol F: C27H38F2O5 Inv Status: Custom Synthesis
Chemical Name: 2-((6S,8S,9R,10S,11S,13S,14S,16R,17S)-6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl pentanoate
Diflucortolone Valerate Impurity 10
CAT No: CL-DFTO-10 CAS No: 36130-02-6 Mol Wt: 460.6 Mol F: C27H37FO5 Inv Status: Custom Synthesis
Chemical Name: 2-((6S,8S,9S,10R,11S,13S,14S,16R,17S)-6-fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl pentanoate
Diflucortolone Valerate Impurity 11
CAT No: CL-DFTO-11 CAS No: NA Mol Wt: 478.6 Mol F: C27H36F2O5 Inv Status: Custom Synthesis
Chemical Name: 2-((6R,8S,9R,10S,11S,13S,14S,16R,17S)-6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl pentanoate
Diflucortolone Valerate Impurity 12
CAT No: CL-DFTO-12 CAS No: 66233-46-3 Mol Wt: 478.6 Mol F: C27H36F2O5 Inv Status: Custom Synthesis
Chemical Name: 2-((6S,8S,9S,10R,11R,12R,13S,14S,16R,17S)-6,12-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl pentanoate
Diflucortolone Valerate Impurity 13
CAT No: CL-DFTO-13 CAS No: NA Mol Wt: 478.6 Mol F: C27H36F2O5 Inv Status: Custom Synthesis
Chemical Name: 2-((6R,8S,9S,10R,11S,13S,14S,16R,17S)-4,6-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl pentanoate, ?4 diflucortolone valerate(JP)
6alpha-Chloro-Diflucortolone Valerate
CAT No: CL-DFTO-14 CAS No: NA Mol Wt: 495 Mol F: C27H36ClFO5 Inv Status: Custom Synthesis
Chemical Name: 2-((6S,8S,9R,10S,11S,13S,16R,17S)-6-chloro-9-fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl pentanoate
9alpha-Chloro-Diflucortolone Valerate
CAT No: CL-DFTO-15 CAS No: NA Mol Wt: 495 Mol F: C27H36ClFO5 Inv Status: Custom Synthesis
Chemical Name: 2-((6S,8S,9R,10S,11S,13S,16R,17S)-9-chloro-6-fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl pentanoate
Butyric Difluocortolone
CAT No: CL-DFTO-16 CAS No: 61633-73-6 Mol Wt: 464.5 Mol F: C26H34F2O5 Inv Status: Custom Synthesis
Chemical Name: 2-((6S,8S,9R,10S,11S,13S,14S,16R,17S)-6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl butyrate
Diflucortolone 17-Carboxylic Acid
CAT No: CL-DFTO-17 CAS No: 1369516-34-6 Mol Wt: 380.4 Mol F: C21H26F2O4 Inv Status: Custom Synthesis
Chemical Name: (6S,8S,9R,10S,11S,13S,14S,16R,17S)-6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carboxylic acid
Diflucortolone Valerate Impurity 15
CAT No: CL-DFTO-18 CAS No: 60535-46-8 Mol Wt: 476.6 Mol F: C27H34F2O5 Inv Status: Custom Synthesis
Chemical Name: 2-((6S,8S,9R,10S,13S,14S,16R,17S)-6,9-difluoro-10,13,16-trimethyl-3,11-dioxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl pentanoate
Diflucortolone Valerate Impurity 17
CAT No: CL-DFTO-19 CAS No: NA Mol Wt: 460.6 Mol F: C27H34F2O4 Inv Status: Custom Synthesis
Chemical Name: 2-((6S,8S,9R,10S,13S,14S,16R,17S)-6,9-difluoro-10,13,16-trimethyl-3-oxo-6,7,8,9,10,13,14,15,16,17-decahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl pentanoate
6alpha-12alpha-Difluocortolone Valerate
CAT No: CL-DFTO-20 CAS No: NA Mol Wt: 496.6 Mol F: C27H35F3O5 Inv Status: Custom Synthesis
Chemical Name: 2-Oxo-2-((6S,8S,9R,10S,11S,12R,13S,14S,16R,17S)-6,9,12-trifluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl)ethyl pentanoate
Diflucortolone Valerate 9,11-Epoxide
CAT No: CL-DFTO-21 CAS No: 65535-29-7 Mol Wt: 458.6 Mol F: C27H35FO5 Inv Status: Custom Synthesis
Chemical Name: 2-((4aS,4bS,5aS,6aS,7S,8R,9aS,9bS,11S)-11-fluoro-4a,6a,8-trimethyl-2-oxo-2,4a,5a,6,6a,7,8,9,9a,9b,10,11-dodecahydrocyclopenta[1,2]phenanthro[4,4a-b]oxiren-7-yl)-2-oxoethyl pentanoate
Diflucortolone Valerate Impurity 14
CAT No: CL-DFTO-22 CAS No: NA Mol Wt: 478.6 Mol F: C27H36F2O5 Inv Status: Custom Synthesis
Chemical Name: 2-((6S,8S,9S,10R,11R,13S,14S,16R,17S)-6,11-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl pentanoate
Diflucortolone Valerate Impurity 16
CAT No: CL-DFTO-23 CAS No: 36130-03-7 Mol Wt: 442.6 Mol F: C27H35FO4 Inv Status: Custom Synthesis
Chemical Name: 2-((6S,8S,10R,13S,14S,16R,17S)-6-fluoro-10,13,16-trimethyl-3-oxo-6,7,8,10,12,13,14,15,16,17-decahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl pentanoate
Fluocortolone 21-Valerate
CAT No: CL-DCVT-24 CAS No: 36130-02-6 Mol Wt: 460.6 Mol F: C27H37FO5 Inv Status: Custom Synthesis
Chemical Name: 2-((6S,8S,9S,10R,11S,13S,14S,16R,17S)-6-fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl pentanoate
Diflucortolone Valerate
CAT No: CL-DFTO-25 CAS No: 59198-70-8 Mol Wt: 478.6 Mol F: C27H36F2O5 Inv Status: Custom Synthesis
Chemical Name: 2-((6S,8S,9R,10S,11S,13S,14S,16R,17S)-6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl pentanoate
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