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Darifenacin is an antimuscarinic agent used to treat overactive bladder with symptoms of urgency, frequency, and incontinence. It selectively targets the M3 muscarinic receptors in the bladder. This selectivity helps reduce side effects like dry mouth and constipation.

Cleanchem is a trusted provider of premium pharmaceutical reference materials, specializing in Darifenacin and its associated compounds. Our catalog includes pharmacopeial and non-pharmacopeial Darifenacin impurities, metabolites, nitrosamine derivatives (N-NO compounds), and stable isotope-labeled products. These reference standards play a critical role in pharmaceutical R&D, supporting activities such as product formulation, ANDA and DMF submissions, quality assurance, analytical method development, and stability assessments.
All Darifenacin-related substances undergo comprehensive characterization and are delivered with complete Certificates of Analysis and supporting analytical documentation to ensure regulatory adherence. Upon request, we can offer EP/USP traceable standards. Our products are routinely re-evaluated to maintain consistent quality and performance.

Darifenacin

CAT No: CL-DFC-01 CAS No: 133099-04-4 Mol Wt: 426.6 Mol F: C28H30N2O2 Inv Status: Custom Synthesis

Chemical Name: (S)-2-(1-(2-(2,3-Dihydrobenzofuran-5-yl)ethyl)pyrrolidin-3-yl)-2,2-diphenylacetamide hydrobromide

Darifenacin R-Isomer

CAT No: CL-DFC-02 CAS No: 133099-05-5 Mol Wt: 426.6 Mol F: C28H30N2O2 Inv Status: Custom Synthesis

Chemical Name: (R)-2-[1-[2-(2,3-Dihydrobenzfuran-5-yl)ethyl]-3-pyrrolidinyl]-2,2-diphenylacetamide

Darifenacin Pyrrolidine Impurity (S)-Isomer

CAT No: CL-DFC-03 CAS No: 134002-26-9 Mol Wt: 280.4 : 150.1 Mol F: C18H20N2O : C4H6O6 Inv Status: In Stock

Chemical Name: (S)-2-(3-Pyrrolidinyl)-2,2-diphenylacetamide L-tartrate

Darifenacin 3-Hydroxy Impurity

CAT No: CL-DFC-04 CAS No: 206048-82-0 Mol Wt: 442.6 Mol F: C28H30N2O3 Inv Status: Custom Synthesis

Chemical Name: 2-{1-[2-(2,3-Dihydro-3-hydroxy-5-benzofuranyl)ethyl]-pyrrolidin-3(S)-yl}-2,2-diphenyl-acetamide

Darifenacin Bromo Impurity

CAT No: CL-DFC-05 CAS No: 127264-14-6 Mol Wt: 227.1 Mol F: C10H11BrO Inv Status: Custom Synthesis

Chemical Name: 5-(2-Bromoethyl)-2,3-dihydrobenzofuran ; 2-(2,3-Dihydrobenzfuran-5-yl)bromoethane

Darifenacin Cyano Pyrrolidine Impurity

CAT No: CL-DFC-07 CAS No: 871505-23-6 Mol Wt: 262.4 : 36.5 Mol F: C18H18N2 : HCl Inv Status: Custom Synthesis

Chemical Name: (S)-3-(Cyanodiphenylmethyl)-pyrrolidine Hydrochloride

Darifenacin DBE Isomer

CAT No: CL-DFC-08 CAS No: NA Mol Wt: 426.6 Mol F: C28H30N2O2 Inv Status: Custom Synthesis

Chemical Name: (S)-2-(3-Pyrrolidinyl)-2,2-diphenyl-N-[2-(2,3-dihydrobenzfuran-5-yl)ethyl] acetamide

Darifenacin Dimer-1 Impurity

CAT No: CL-DFC-09 CAS No: NA Mol Wt: 572.7 Mol F: C38H40N2O3 Inv Status: Custom Synthesis

Chemical Name: S)-2-(3-Pyrrolidinyl)-2,2-diphenyl-N,N-bis[2-(2,3-dihydrobenzfuran-5-yl)ethyl]acetamide

Darifenacin Dimer-2 Impurity

CAT No: CL-DFC-10 CAS No: 2280857-32-9 Mol Wt: 572.7 Mol F: C38H40N2O3 Inv Status: Custom Synthesis

Chemical Name: (S)-N-(2-(2,3-Dihydrobenzofuran-5-yl)ethyl)-2-(1-(2-(2,3-dihydrobenzofuran-5-yl)ethyl)pyrrolidin-3-yl)-2,2-diphenylacetamide

Darifenacin Nitrile Impurity

CAT No: CL-DFC-11 CAS No: 252317-48-9 Mol Wt: 408.5 Mol F: C28H28N2O Inv Status: Custom Synthesis

Chemical Name: (3S)-1-[2-(2,3-Dihydro-5-benzofuranyl)ethyl]-?,?-diphenyl-3-pyrrolidine acetonitrile

Darifenacin Pyrrolidine Impurity Racemate

CAT No: CL-DFC-12 CAS No: 103887-32-7 Mol Wt: 280.4 Mol F: C18H20N2O Inv Status: Custom Synthesis

Chemical Name: 2-(3-Pyrrolidinyl)-2,2-diphenylacetamide ; 2,2-Diphenyl-2-(pyrrolidine-3-yl)acetamide

Darifenacin Cyano T-BOC Impurity

CAT No: CL-DFC-13 CAS No: 1159977-31-7 Mol Wt: 362.5 Mol F: C23H26N2O2 Inv Status: Custom Synthesis

Chemical Name: 3-(Cyanodiphenylmethyl)-1-pyrrolidinecarboxylic acid t-butyl ester

Darifenacin 2,3-Dehydro Bromo Impurity

CAT No: CL-DFC-14 CAS No: 133034-06-7 Mol Wt: 225.1 Mol F: C10H9BrO Inv Status: Custom Synthesis

Chemical Name: 5-(2-Bromoethyl)benzofuran

Darifenacin 4-Hydroxy Impurity

CAT No: CL-DFC-15 CAS No: 2468796-89-4 Mol Wt: 507.5 Mol F: C28H31BrN2O2 Inv Status: Custom Synthesis

Chemical Name: (S)-2-(1-(3-(2-bromoethyl)-4-hydroxyphenethyl)pyrrolidin-3-yl)-2,2-diphenylacetamide

Darifenacin 7-Bromo Analog

CAT No: CL-DFC-16 CAS No: 1391080-43-5 Mol Wt: 505.5 Mol F: C28H29BrN2O2 Inv Status: Custom Synthesis

Chemical Name: (S)-2-(1-(2-(7-Bromo-2,3-dihydrobenzofuran-5-yl)ethyl)pyrrolidin-3-yl)-2,2-diphenylacetamide

Darifenacin 7-Bromoethyl Impurity

CAT No: CL-DFC-17 CAS No: 1598271-92-1 Mol Wt: 227.1 Mol F: C10H11BrO Inv Status: Custom Synthesis

Chemical Name: 7-(2-Bromoethyl)-2,3-dihydrobenzofuran

Darifenacin Carboxylic Acid Impurity

CAT No: CL-DFC-18 CAS No: 1048979-16-3 Mol Wt: 427.5 Mol F: C28H29NO3 Inv Status: Custom Synthesis

Chemical Name: (S)-2-(1-(2-(2,3-Dihydrobenzofuran-5-yl)ethyl)pyrrolidin-3-yl)-2,2-diphenylacetic acid

Darifenacin N-Oxide Impurity

CAT No: CL-DFC-19 CAS No: 1391080-40-2 Mol Wt: 442.6 Mol F: C28H30N2O3 Inv Status: Custom Synthesis

Chemical Name: (S)-2-[ 1-[2-(2,3-Dihydrobenzofuran-5-yl)ethyl]-1 -oxidopyrrolidin-3-yl]-2,2-diphenyl acetamide

Darifenacin Pyrrolidin Carboxylic Acid Impurity

CAT No: CL-DFC-20 CAS No: 1050646-75-7 Mol Wt: 281.4 Mol F: C18H19NO2 Inv Status: Custom Synthesis

Chemical Name: (S)-2,2-Diphenyl-2-(pyrrolidin-3-yl)acetic acid

Darifenacin Pyrrolidinium Dimer Impurity

CAT No: CL-DFC-21 CAS No: 1396968-57-2 Mol Wt: 573.8 : 79.9 Mol F: C38H41N2O3 : Br Inv Status: Custom Synthesis

Chemical Name: (3S)-3-(2-Amino-2-oxo-1,1-diphenylethyl)-1,1-bis[2-(2,3-dihydro-5-benzofuranyl)ethyl]pyrrolidinium Bromide

Darifenacin Vinylbenzofuran Impurity

CAT No: CL-DFC-22 CAS No: 633335-98-5 Mol Wt: 144.2 Mol F: C10H8O Inv Status: Custom Synthesis

Chemical Name: 5-Vinylbenzofuran

Darifenacin Impurity (UK-156961)

CAT No: CL-DFC-23 CAS No: 206048-83-1 Mol Wt: 444.6 Mol F: C28H32N2O3 Inv Status: Custom Synthesis

Chemical Name: 1-[2-[4-Hydroxy-3-(2-hydroxyethyl)phenyl]ethyl]-?,?-diphenyl-3-pyrrolidineacetamide

Darifenacin Oxidized Impurity

CAT No: CL-DFC-24 CAS No: 133033-99-5 Mol Wt: 424.5 Mol F: C28H28N2O2 Inv Status: Custom Synthesis

Chemical Name: (S)-2-(1-(2-(Benzofuran-5-yl)ethyl)pyrrolidin-3-yl)-2,2-diphenylacetamide

Darifenacin Impurity E

CAT No: CL-DFC-25 CAS No: 1797983-04-0 Mol Wt: 572.7 Mol F: C38H40N2O3 Inv Status: Custom Synthesis

Chemical Name: 4-(2-(Bis(2-(2,3-dihydrobenzofuran-5-yl)ethyl)amino)ethyl)-3,3-diphenylpyrrolidin-2-one

Darifenacin Impurity H

CAT No: CL-DFC-26 CAS No: NA Mol Wt: 718.9 Mol F: C47H50N4O3 Inv Status: Custom Synthesis

Chemical Name: N-((3-(2-Amino-2-oxo-1,1-diphenylethyl)pyrrolidin-1-yl)methyl)-2-((S)-1-(2-(2,3-dihydrobenzofuran-5-yl)ethyl)pyrrolidin-3-yl)-2,2-diphenylacetamide

Darifenacin Vinyl Impurity (UK-201705)

CAT No: CL-DFC-27 CAS No: 1048979-09-4 Mol Wt: 426.6 Mol F: C28H30N2O2 Inv Status: Custom Synthesis

Chemical Name: (3S)-1-[2-(3-Ethenyl-4-hydroxyphenyl)ethyl]-?,?-diphenyl-3-pyrrolidineacetamide

Darifenacin Impurity 1

CAT No: CL-DFC-28 CAS No: 133099-09-9 Mol Wt: 416.6 Mol F: C25H24N2O2S Inv Status: Custom Synthesis

Chemical Name: (S)-2,2-Diphenyl-2-(1-tosylpyrrolidin-3-yl)acetonitrile

Darifenacin Impurity 2

CAT No: CL-DFC-29 CAS No: 133099-10-2 Mol Wt: 416.6 Mol F: C25H24N2O2S Inv Status: Custom Synthesis

Chemical Name: (R)-2,2-Diphenyl-2-(1-tosylpyrrolidin-3-yl)acetonitrile

Darifenacin Morpholine Amide Impurity

CAT No: CL-DFC-30 CAS No: 97483-11-9 Mol Wt: 263.4 Mol F: C14H17NO2S Inv Status: Custom Synthesis

Chemical Name: Ethanethione, 2-?(2,?3-?dihydro-?5-?benzofuranyl)?-?1-?(4-?morpholinyl)?-; Morpholine, 4-[2-(2,3-dihydro-5-benzofuranyl)-1-thioxoethyl]- (9CI); 2-(2,3-Dihydro-5-benzofuranyl)-1-(4-morpholinyl)ethanethione

Darifenacin Impurity 3

CAT No: CL-DFC-31 CAS No: 86-29-3 Mol Wt: 193.3 Mol F: C14H11N Inv Status: Custom Synthesis

Chemical Name: ?-Phenylbenzeneacetonitrile

Darifenacin Impurity 5

CAT No: CL-DFC-32 CAS No: NA Mol Wt: 422.5 Mol F: C20H22O6S2 Inv Status: Custom Synthesis

Chemical Name: 2,2'-((Disulfanediylbis(ethane-2,1-diyl))bis(4-hydroxy-3,1-phenylene))diacetic acid

Darifenacin Impurity 6

CAT No: CL-DFC-33 CAS No: 133034-07-8 Mol Wt: 440.6 Mol F: C28H28N2O3 Inv Status: Custom Synthesis

Chemical Name: (S)-2-(1-(2-(2,3-Dihydrobenzofuran-5-yl)-2-oxoethyl)pyrrolidin-3-yl)-2,2-diphenylacetamide

Darifenacin Impurity 7

CAT No: CL-DFC-34 CAS No: NA Mol Wt: 294.4 Mol F: C19H22N2O Inv Status: Custom Synthesis

Chemical Name: (S)-N-Methyl-2,2-diphenyl-2-(pyrrolidin-3-yl)acetamide

Darifenacin KSM-I A

CAT No: CL-DFC-35 CAS No: 90843-31-5 Mol Wt: 162.2 Mol F: C10H10O2 Inv Status: Custom Synthesis

Chemical Name: 1-(2,3-Dihydrobenzofuran-5-yl)ethanone

Darifenacin KSM-II B Precursor

CAT No: CL-DFC-36 CAS No: 133034-01-2 Mol Wt: 395.5 Mol F: C18H21NO5S2 Inv Status: Custom Synthesis

Chemical Name: 1(S)-1-Tosylpyrrolidin-3-yl 4-methylbenzenesulfonate

Darifenacin KSM-II C Precursor

CAT No: CL-DFC-37 CAS No: 943587-25-5 Mol Wt: 241.3 Mol F: C11H15NO3S Inv Status: Custom Synthesis

Chemical Name: (S)-1-Tosylpyrrolidin-3-ol

Darifenacin Impurity 8

CAT No: CL-DFC-38 CAS No: 87776-76-9 Mol Wt: 164.2 Mol F: C10H12O2 Inv Status: Custom Synthesis

Chemical Name: 2,3-Dihydro-5-benzofuranethanol ; 5-(2-Hydroxyethyl)-2,3-dihydrobenzofuran

Darifenacin Impurity B

CAT No: CL-DFC-39 CAS No: 136081-60-2 Mol Wt: 242.3 Mol F: C11H14O4S Inv Status: Custom Synthesis

Chemical Name: 2,3-Dihydro-5-benzofuranethanol Methanesulfonate

Darifenacin Impurity 9

CAT No: CL-DFC-40 CAS No: 142935-60-2 Mol Wt: 176.2 Mol F: C10H8O3 Inv Status: Custom Synthesis

Chemical Name: 5-Benzofuranacetic Acid ; Benzofuran-5-ylacetic Acid ; 2-(Benzofuran-5-yl)acetic Acid ; Darifenacin-Benzofuran-5YL-Acetic acid

Darifenacin Impurity 10

CAT No: CL-DFC-41 CAS No: 1092540-94-7 Mol Wt: 280.4 : 150.1 Mol F: C18H20N2O : C4H6O6 Inv Status: Custom Synthesis

Chemical Name: 2,2-Diphenyl-2-[(3R)-3-pyrrolidinyl]acetamide 2,3-dihydroxysuccinate (1:1)

Darifenacin Impurity 11

CAT No: CL-DFC-42 CAS No: 1048979-15-2 Mol Wt: 383.5 Mol F: C27H29NO Inv Status: Custom Synthesis

Chemical Name: (S)-3-Benzhydryl-1-(2-(2,3-dihydrobenzofuran-5-yl)ethyl)pyrrolidine

Darifenacin Impurity 12

CAT No: CL-DFC-43 CAS No: NA Mol Wt: 383.5 Mol F: C27H29NO Inv Status: Custom Synthesis

Chemical Name: (S)-4-(2-(3-Benzhydrylpyrrolidin-1-yl)ethyl)-2-vinylphenol

Darifenacin 5-Carboxymethyl Impurity

CAT No: CL-DFC-44 CAS No: 69999-16-2 Mol Wt: 178.2 Mol F: C10H10O3 Inv Status: Custom Synthesis

Chemical Name: 2,3-Dihydro-5-benzofuranacetic acid

Darifenacin Nitrile Impurity (HCl)

CAT No: CL-DFC-45 CAS No: NA Mol Wt: 408.5 : 36.5 Mol F: C28H28N2O : HCl Inv Status: Custom Synthesis

Chemical Name: (3S)-1-[2-(2,3-Dihydro-5-benzofuranyl)ethyl]-?,?-diphenyl-3-pyrrolidine acetonitrile hydrochloride

Darifenacin Hydrochloride

CAT No: CL-DFC-46 CAS No: 586346-94-3 Mol Wt: 426.6 : 36.5 Mol F: C28H30N2O2 : HCl Inv Status: Custom Synthesis

Chemical Name: (S)-2-(1-(2-(2,3-Dihydrobenzofuran-5-yl)ethyl)pyrrolidin-3-yl)-2,2-diphenylacetamide hydrochloride

Darifenacin Hydrobromide

CAT No: CL-DFC-47 CAS No: 133099-07-7 Mol Wt: 426.6 : 80.9 Mol F: C28H30N2O2 : HBr Inv Status: Custom Synthesis

Chemical Name: (S)-2-(1-(2-(2,3-Dihydrobenzofuran-5-yl)ethyl)pyrrolidin-3-yl)-2,2-diphenylacetamide hydrobromide

Darifenacin R-Isomer (HCl)

CAT No: CL-DFC-48 CAS No: NA Mol Wt: 426.6 : 36.5 Mol F: C28H30N2O2 : HCl Inv Status: Custom Synthesis

Chemical Name: (R)-2-[1-[2-(2,3-Dihydrobenzfuran-5-yl)ethyl]-3-pyrrolidinyl]-2,2-diphenylacetamide Hydrochloride

Darifenacin Impurity 10 (Tartarate salt)

CAT No: CL-DFC-49 CAS No: 1092540-94-7 Mol Wt: 280.4 : 150.1 Mol F: C18H20N2O : C4H6O6 Inv Status: Custom Synthesis

Chemical Name: 2,2-Diphenyl-2-[(3R)-3-pyrrolidinyl]acetamide 2,3-dihydroxysuccinate (1:1)

Darifenacin Impurity 13

CAT No: CL-DFC-50 CAS No: NA Mol Wt: 718.9 Mol F: C46H46N4O4 Inv Status: Custom Synthesis

Chemical Name: N-((S)-3-(2-Amino-2-oxo-1,1-diphenylethyl)pyrrolidin-1-yl)-2-((S)-1-(2-(2,3-dihydrobenzofuran-5-yl)ethyl)-2-oxopyrrolidin-3-yl)-2,2-diphenylacetamide

Darifenacin Recemic Mixture

CAT No: CL-DFC-51 CAS No: 133033-93-9 Mol Wt: 426.6 Mol F: C28H30N2O2 Inv Status: Custom Synthesis

Chemical Name: 2-(1-(2-(2,3-Dihydrobenzofuran-5-yl)ethyl)pyrrolidin-3-yl)-2,2-diphenylacetamide

Darifenacin Impurity D

CAT No: CL-DFC-52 CAS No: NA Mol Wt: 424.5 Mol F: C28H28N2O2 Inv Status: Custom Synthesis

Chemical Name: {2-[1-(2-Benzofuran-5-yl)ethyl]pyrrolidin-3-yl}-2,2-diphenylacetamide

Darifenacin D4

CAT No: CL-DFC-53 CAS No: 1095598-84-7 Mol Wt: 430.6 Mol F: C28H26D4N2O2 Inv Status: Custom Synthesis

Chemical Name: (S)-2-(1-(2-(2,3-Dihydrobenzofuran-5-yl)ethyl-1,1,2,2-d4)pyrrolidin-3-yl)-2,2-diphenylacetamide

Type:Impurity Reference Standard

Total Products: 52

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Darifenacin is an antimuscarinic agent used to treat overactive bladder with symptoms of urgency, frequency, and incontinence. It selectively targets the M3 muscarinic receptors in the bladder. This selectivity helps reduce side effects like dry mouth and constipation.

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