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Buprenorphine is an opioid used to treat opioid addiction and manage pain. It acts as a partial agonist at opioid receptors, providing relief from withdrawal symptoms and cravings, without the full effects of opioids like heroin or morphine. It is used in both addiction treatment and pain management.
Cleanchem is a trusted provider of premium pharmaceutical reference materials, specializing in Buprenorphine and its associated compounds. Our catalog includes pharmacopeial and non-pharmacopeial Buprenorphine impurities, metabolites, nitrosamine derivatives (N-NO compounds), and stable isotope-labeled products. These reference standards play a critical role in pharmaceutical R&D, supporting activities such as product formulation, ANDA and DMF submissions, quality assurance, analytical method development, and stability assessments.
All Buprenorphine-related substances undergo comprehensive characterization and are delivered with complete Certificates of Analysis and supporting analytical documentation to ensure regulatory adherence. Upon request, we can offer EP/USP traceable standards. Our products are routinely re-evaluated to maintain consistent quality and performance.

Buprenorphine EP Impurity A
CAT No: CL-BPRP-001 CAS No: 457071-73-7 Mol Wt: 467.7 Mol F: C29H41NO4 Inv Status: Custom Synthesis
Chemical Name: (4R,4aS,6R,7R,7aR,12bS)-3-(but-3-en-1-yl)-6-((S)-2-hydroxy-3,3-dimethylbutan-2-yl)-7-methoxy-1,2,3,4,5,6,7,7a-octahydro-4a,7-ethano-4,12-methanobenzofuro[3,2-e]isoquinolin-9-ol
Buprenorphine EP Impurity B
CAT No: CL-BPRP-002 CAS No: 78715-23-8 Mol Wt: 413.6 Mol F: C25H35NO4 Inv Status: Custom Synthesis
Chemical Name: (4R,4aS,6R,7R,7aR,12bS)-6-((S)-2-hydroxy-3,3-dimethylbutan-2-yl)-7-methoxy-1,2,3,4,5,6,7,7a-octahydro-4a,7-ethano-4,12-methanobenzofuro[3,2-e]isoquinolin-9-ol
Buprenorphine EP Impurity C
CAT No: CL-BPRP-003 CAS No: 16614-60-1 Mol Wt: 452.6 Mol F: C27H36N2O4 Inv Status: Custom Synthesis
Chemical Name: (4R,4aS,6R,7R,7aR,12bS)-6-((S)-2-hydroxy-3,3-dimethylbutan-2-yl)-7,9-dimethoxy-1,2,5,6,7,7a-hexahydro-4a,7-ethano-4,12-methanobenzofuro[3,2-e]isoquinoline-3(4H)-carbonitrile
Buprenorphine EP Impurity D
CAT No: CL-BPRP-004 CAS No: 16524-65-5 Mol Wt: 481.7 Mol F: C30H43NO4 Inv Status: Custom Synthesis
Chemical Name: (S)-2-((4R,4aS,6R,7R,7aR,12bS)-3-(cyclopropylmethyl)-7,9-dimethoxy-1,2,3,4,5,6,7,7a-octahydro-4a,7-ethano-4,12-methanobenzofuro[3,2-e]isoquinolin-6-yl)-3,3-dimethylbutan-2-ol
Buprenorphine EP Impurity E
CAT No: CL-BPRP-005 CAS No: 130668-48-3 Mol Wt: 453.6 Mol F: C28H39NO4 Inv Status: Custom Synthesis
Chemical Name: (4R,4aS,6R,7R,7aR,12bS)-3-(cyclopropylmethyl)-6-((S)-2-hydroxy-3,3-dimethylbutan-2-yl)-1,2,3,4,5,6,7,7a-octahydro-4a,7-ethano-4,12-methanobenzofuro[3,2-e]isoquinoline-7,9-diol
Buprenorphine EP Impurity F
CAT No: CL-BPRP-006 CAS No: 97203-04-8 Mol Wt: 449.6 Mol F: C29H39NO3 Inv Status: Custom Synthesis
Chemical Name: (4R,4aS,6R,7R,7aR,12bS)-3-(cyclopropylmethyl)-6-(3,3-dimethylbut-1-en-2-yl)-7-methoxy-1,2,3,4,5,6,7,7a-octahydro-4a,7-ethano-4,12-methanobenzofuro[3,2-e]isoquinolin-9-ol
Buprenorphine EP Impurity G
CAT No: CL-BPRP-007 CAS No: NA Mol Wt: 933.3 Mol F: C58H80N2O8 Inv Status: Custom Synthesis
Chemical Name: (4R,4'R,5S,5'S,7R,7'R,8R,8'R,9R,9'R,17S,17'S)-3,3'-bis(cyclopropylmethyl)-7,7'-bis((S)-2-hydroxy-3,3-dimethylbutan-2-yl)-8,8'-dimethoxy-2,2',3,3',4,4',6,6',7,7',8,8',9,9',18,18',19,19',20,20'-icosahydro-1H,1'H-[13,13'-bi(4a,7-ethano-4,12-methanobenzofuro[3,2-e]isoquinoline)]-12,12'-diol
Buprenorphine EP Impurity H
CAT No: CL-BPRP-008 CAS No: 90387-35-2 Mol Wt: 469.7 Mol F: C29H43NO4 Inv Status: Custom Synthesis
Chemical Name: (4R,4aS,6R,7R,7aR,12bS)-3-butyl-6-((S)-2-hydroxy-3,3-dimethylbutan-2-yl)-7-methoxy-1,2,3,4,5,6,7,7a-octahydro-4a,7-ethano-4,12-methanobenzofuro[3,2-e]isoquinolin-9-ol
Buprenorphine EP Impurity I
CAT No: CL-BPRP-009 CAS No: 89663-73-0 Mol Wt: 435.6 Mol F: C28H37NO3 Inv Status: Custom Synthesis
Chemical Name: (4bS,8R,8aS,9aR,12aR,12bR)-7-(cyclopropylmethyl)-10,10,11,11-tetramethyl-6,7,8,9,9a,10,11,12b-octahydro-5H-8a,12a-ethano-4,8-methanobenzofuro[3,2-e]furo[2,3-g]isoquinolin-1-ol
Buprenorphine EP Impurity J
CAT No: CL-BPRP-010 CAS No: 155203-05-7 Mol Wt: 465.6 Mol F: C29H39NO4 Inv Status: Custom Synthesis
Chemical Name: (4R,4aR,7R,7aR,12bS,14R)-3-(cyclopropylmethyl)-14-((S)-2-hydroxy-3,3-dimethylbutan-2-yl)-7-methoxy-1,2,3,4,7,7a-hexahydro-7,4a-ethano-4,12-methanobenzofuro[3,2-e]isoquinolin-9-ol
Buprenorphine N-Oxide
CAT No: CL-BPRP-011 CAS No: NA Mol Wt: 483.6 Mol F: C29H41NO5 Inv Status: Custom Synthesis
Chemical Name: (3R,4R,4aS,6R,7R,7aR,12bS)-3-(cyclopropylmethyl)-9-hydroxy-6-((S)-2-hydroxy-3,3-dimethylbutan-2-yl)-7-methoxy-1,2,3,4,5,6,7,7a-octahydro-4a,7-ethano-4,12-methanobenzofuro[3,2-e]isoquinoline 3-oxide
10-Oxo Buprenorphine
CAT No: CL-BPRP-012 CAS No: 1044710-08-8 Mol Wt: 481.6 Mol F: C29H39NO5 Inv Status: Custom Synthesis
Chemical Name: (4S,4aS,6R,7R,7aR,12bS)-3-(cyclopropylmethyl)-9-hydroxy-6-((S)-2-hydroxy-3,3-dimethylbutan-2-yl)-7-methoxy-1,2,3,4,5,6,7,7a-octahydro-4a,7-ethano-4,12-methanobenzofuro[3,2-e]isoquinolin-13-one
Hydroxy Buprenorphine
CAT No: CL-BPRP-014 CAS No: NA Mol Wt: 483.6 Mol F: C29H41NO5 Inv Status: Custom Synthesis
Chemical Name: 3-(cyclopropylmethyl)-6-(2-hydroxy-3,3-dimethylbutan-2-yl)-7-methoxy-1,2,3,4,5,6,7,7a-octahydro-4a,7-ethano-4,12-methanobenzofuro[3,2-e]isoquinoline-9,13-diol
Hydroxy Norbuprenorphine
CAT No: CL-BPRP-015 CAS No: NA Mol Wt: 429.6 Mol F: C25H35NO5 Inv Status: Custom Synthesis
Chemical Name: (4S,4aS,6R,7R,7aR,12bS)-6-((S)-2-hydroxy-3,3-dimethylbutan-2-yl)-7-methoxy-1,2,3,4,5,6,7,7a-octahydro-4a,7-ethano-4,12-methanobenzofuro[3,2-e]isoquinoline-9,13-diol
3-O-Methyl Norbuprenorphine
CAT No: CL-BPRP-016 CAS No: 16614-59-8 Mol Wt: 427.6 Mol F: C26H37NO4 Inv Status: Custom Synthesis
Chemical Name: (S)-2-((4R,4aS,6R,7R,7aR,12bS)-7,9-dimethoxy-1,2,3,4,5,6,7,7a-octahydro-4a,7-ethano-4,12-methanobenzofuro[3,2-e]isoquinolin-6-yl)-3,3-dimethylbutan-2-ol
Buprenorphine Beta-D-Glucuronide
CAT No: CL-BPRP-017 CAS No: 101224-22-0 Mol Wt: 643.8 Mol F: C35H49NO10 Inv Status: Custom Synthesis
Chemical Name: (2S,3S,4S,5R,6S)-6-(((4R,4aS,6R,7R,7aR,12bS)-3-(cyclopropylmethyl)-6-((S)-2-hydroxy-3,3-dimethylbutan-2-yl)-7-methoxy-1,2,3,4,5,6,7,7a-octahydro-4a,7-ethano-4,12-methanobenzofuro[3,2-e]isoquinolin-9-yl)oxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid
Buprenorphine Oxo Impurity
CAT No: CL-BPRP-018 CAS No: NA Mol Wt: 481.6 Mol F: C29H39NO5 Inv Status: Custom Synthesis
Chemical Name: (4R,4aS,6R,7R,7aR,12bS)-3-(cyclopropylmethyl)-9-hydroxy-6-((S)-2-hydroxy-3,3-dimethylbutan-2-yl)-7-methoxy-3,4,5,6,7,7a-hexahydro-4a,7-ethano-4,12-methanobenzofuro[3,2-e]isoquinolin-2(1H)-one
N-Methyl Norbuprenorphine 3-Methyl Ether
CAT No: CL-BPRP-019 CAS No: 16196-70-6 Mol Wt: 441.6 Mol F: C27H39NO4 Inv Status: Custom Synthesis
Chemical Name: (S)-2-((4R,4aS,6R,7R,7aR,12bS)-7,9-dimethoxy-3-methyl-1,2,3,4,5,6,7,7a-octahydro-4a,7-ethano-4,12-methanobenzofuro[3,2-e]isoquinolin-6-yl)-3,3-dimethylbutan-2-ol
Norbuprenorphine 3-Beta-D-Glucuronide
CAT No: CL-BPRP-020 CAS No: 469887-29-4 Mol Wt: 589.7 Mol F: C31H43NO10 Inv Status: Custom Synthesis
Chemical Name: (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4R,4aS,6R,7R,7aR,12bS)-6-((S)-2-hydroxy-3,3-dimethylbutan-2-yl)-7-methoxy-1,2,3,4,5,6,7,7a-octahydro-4a,7-ethano-4,12-methanobenzofuro[3,2-e]isoquinolin-9-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid
7-(S)-Buprenorphine
CAT No: CL-BPRP-021 CAS No: 152610-73-6 Mol Wt: 467.7 Mol F: C29H41NO4 Inv Status: Custom Synthesis
Chemical Name: (4R,4aS,6S,7R,7aR,12bS)-3-(cyclopropylmethyl)-6-((S)-2-hydroxy-3,3-dimethylbutan-2-yl)-7-methoxy-1,2,3,4,5,6,7,7a-octahydro-4a,7-ethano-4,12-methanobenzofuro[3,2-e]isoquinolin-9-ol
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