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Amitriptyline is a tricyclic antidepressant used to treat depression, chronic pain, migraines, and neuropathic pain. It works by inhibiting the reuptake of serotonin and norepinephrine in the brain. Its sedative effects are useful for insomnia associated with depression. Side effects include dry mouth, constipation, and cardiac arrhythmias in overdose.

Cleanchem is a trusted provider of premium pharmaceutical reference materials, specializing in Amitriptyline and its associated compounds. Our catalog includes pharmacopeial and non-pharmacopeial Amitriptyline impurities, metabolites, nitrosamine derivatives (N-NO compounds), and stable isotope-labeled products. These reference standards play a critical role in pharmaceutical R&D, supporting activities such as product formulation, ANDA and DMF submissions, quality assurance, analytical method development, and stability assessments.
All Amitriptyline-related substances undergo comprehensive characterization and are delivered with complete Certificates of Analysis and supporting analytical documentation to ensure regulatory adherence. Upon request, we can offer EP/USP traceable standards. Our products are routinely re-evaluated to maintain consistent quality and performance.

Amitriptyline Hydrochloride

CAT No: CL-AMPT-01 CAS No: 549-18-8 Mol Wt: 277.4 : 36.5 Mol F: C20H23N : HCl Inv Status: In Stock

Chemical Name: 3-(10,11-Dihydro-5H-dibenzo[a,d]cycloheptene-5-ylidene)-N,N-dimethylpropan-1-amine Hydrochloride

Amitriptyline EP Impurity A

CAT No: CL-AMPT-02 CAS No: 1210-35-1 Mol Wt: 208.3 Mol F: C15H12O Inv Status: In Stock

Chemical Name: 10,11-Dihydro-5H-dibenzo[a,d][7]annulen-5-one; Amitriptyline USP RC A; Dibenzosuberone; Dibenzosuberone ; 10,11-Dihydro-5H-dibenzo[a,d][7]annulen-5-one

Amitriptyline EP Impurity B

CAT No: CL-AMPT-03 CAS No: 6202-23-9 Mol Wt: 275.4 : 36.5 Mol F: C20H21N : HCl Inv Status: Custom Synthesis

Chemical Name: 3-(5H-Dibenzo[a,d][7]annulen-5-ylidene)-N,N-dimethylpropan-1-amine hydrochloride; Cyclobenzaprine HCl

Amitriptyline EP Impurity C

CAT No: CL-AMPT-04 CAS No: 72-69-5 Mol Wt: 263.4 Mol F: C19H21N Inv Status: Custom Synthesis

Chemical Name: 3-(10,11-Dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)-N-methylpropan-1-amine

Amitriptyline EP Impurity D

CAT No: CL-AMPT-05 CAS No: 1159-03-1 Mol Wt: 295.4 Mol F: C20H25NO Inv Status: Custom Synthesis

Chemical Name: 5-[3-(Dimethylamino)propyl]-10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-ol; Amitriptyline USP RC B; Amitriptynol

Amitriptyline EP Impurity E

CAT No: CL-AMPT-06 CAS No: NA Mol Wt: 283.5 : 36.5 Mol F: C20H29N : HCl Inv Status: Custom Synthesis

Chemical Name: N,N-Dimethyl-3-(1,2,3,4,4a,10,11,11a-octahydro-5H-dibenzo[a,d][7]annulen-5-ylidene)propan-1-amine HCl

Amitriptyline EP Impurity F

CAT No: CL-AMPT-07 CAS No: 64520-05-4 Mol Wt: 293.4 Mol F: C20H23NO Inv Status: Custom Synthesis

Chemical Name: (R,E)-5-(3-(Dimethylamino)propylidene)-10,11-dihydro-5H-dibenzo[a,d][7]annulen-10-ol

Amitriptyline EP Impurity G

CAT No: CL-AMPT-08 CAS No: 1210-34-0 Mol Wt: 210.3 Mol F: C15H14O Inv Status: Custom Synthesis

Chemical Name: 10,11-Dihydro-5H-dibenzo[a,d][7]annulen-5-ol

Amitriptyline N-Oxide

CAT No: CL-AMPT-09 CAS No: 4317-14-0 Mol Wt: 293.4 Mol F: C20H23NO Inv Status: In Stock

Chemical Name: 3-(10,11-Dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)-N,N-dimethylpropan-1-amine oxide

Amitriptyline Impurity 1

CAT No: CL-AMPT-11 CAS No: 24755-73-5 Mol Wt: 232.3 Mol F: C18H16 Inv Status: Custom Synthesis

Chemical Name: 5-Allylidene-10,11-dihydro-5H-dibenzo[a,d][7]annulene

10-Hydroxy Amitriptyline Oxalate

CAT No: CL-AMPT-12 CAS No: 1246833-15-7 Mol Wt: 293.4 : 90.0 Mol F: C20H23NO : C2H2O4 Inv Status: Custom Synthesis

Chemical Name: 5-[3-(Dimethylamino)propylidene]-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-10-ol Oxalate

Dibenzocyclo Heptenol

CAT No: CL-AMPT-13 CAS No: 10354-00-4 Mol Wt: 208.3 Mol F: C15H12O Inv Status: Custom Synthesis

Chemical Name: 5H-Dibenzo[a,d][7]annulen-5-ol

Amitriptyline

CAT No: CL-AMPT-14 CAS No: 50-48-6 Mol Wt: 277.4 Mol F: C20H23N Inv Status: Custom Synthesis

Chemical Name: 3-(10,11-Dihydro-5H-dibenzo[a,d]cycloheptene-5-ylidene)-N,N-dimethylpropan-1-amine

Amitriptyline N-Glucuronide

CAT No: CL-AMPT-15 CAS No: 112806-33-4 Mol Wt: 453.5 Mol F: C19H21N Inv Status: Custom Synthesis

Chemical Name: 3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-b-D-glucopyranuronosyl-N,N-dimethyl-1-propanaminium Inner Salt

2-Benzoylphenylacetic acid

CAT No: CL-AMPT-16 CAS No: 23107-96-2 Mol Wt: 240.3 Mol F: C15H12O3 Inv Status: Custom Synthesis

Chemical Name: 2-Benzoylphenylacetic acid

Amitriptyline-D3 Hydrochloride

CAT No: CL-AMPT-17 CAS No: 342611-00-1 Mol Wt: 280.4 : 36.5 Mol F: C20H20D3N : HCl Inv Status: Custom Synthesis

Chemical Name: 3-(10,11-Dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)-N-methyl-N-(methyl-d3)propan-1-amine hydrochloride

Amitriptyline D6 Hydrochloride

CAT No: CL-AMPT-18 CAS No: 203645-63-0 Mol Wt: 283.5 : 36.5 Mol F: C20H17D6N : HCl Inv Status: Custom Synthesis

Chemical Name: 3-(10,11-Dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)-N,N-bis(methyl-d3)propan-1-amine hydrochloride

Type:Impurity Reference Standard

Total Products: 17

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