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Type:Impurity Reference Standard
Total Products: 60
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Afatinib Related Products
Cleanchem is a trusted provider of premium pharmaceutical reference materials, specializing in Afatinib and its associated compounds. Our catalog includes pharmacopeial and non-pharmacopeial Afatinib impurities, metabolites, nitrosamine derivatives (N-NO compounds), and stable isotope-labeled products. These reference standards play a critical role in pharmaceutical R&D, supporting activities such as product formulation, ANDA and DMF submissions, quality assurance, analytical method development, and stability assessments.
All Afatinib-related substances undergo comprehensive characterization and are delivered with complete Certificates of Analysis and supporting analytical documentation to ensure regulatory adherence. Upon request, we can offer EP/USP traceable standards. Our products are routinely re-evaluated to maintain consistent quality and performance.
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Afatinib
CAT No: CL-ATB-01 CAS No: 850140-72-6 Mol Wt: 485.9 Mol F: C24H25ClFN5O3 Inv Status: In Stock
Chemical Name: (S,E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide
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Afatinib Impurity A
CAT No: CL-ATB-02 CAS No: 402855-07-6 Mol Wt: 404.8 Mol F: C18H14ClFN4O4 Inv Status: Custom Synthesis
Chemical Name: (R)-N-(3-Chloro-4-fluorophenyl)-6-nitro-7-((tetrahydrofuran-3-yl)oxy)quinazolin-4-amine
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Afatinib Impurity B
CAT No: CL-ATB-03 CAS No: 314771-76-1 Mol Wt: 374.8 Mol F: C18H16ClFN4O2 Inv Status: Custom Synthesis
Chemical Name: N4-(3-Chloro-4-fluorophenyl)-7-[[(3S)-tetrahydro-3-furanyl]oxy]-4,6-quinazolinediamine
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Afatinib Impurity C
CAT No: CL-ATB-04 CAS No: 945553-91-3 Mol Wt: 486 Mol F: C24H25ClFN5O3 Inv Status: Custom Synthesis
Chemical Name: (R,E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide
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Afatinib Impurity D
CAT No: CL-ATB-05 CAS No: 1680184-59-1 Mol Wt: 485.9 Mol F: C24H25ClFN5O3 Inv Status: Custom Synthesis
Chemical Name: (S,Z)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide
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Afatinib Impurity E
CAT No: CL-ATB-06 CAS No: 2223677-63-0 Mol Wt: 502.4 Mol F: C24H25Cl2N5O3 Inv Status: Custom Synthesis
Chemical Name: (S,E)-N-(4-((3,4-dichlorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide
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Afatinib Impurity F
CAT No: CL-ATB-07 CAS No: NA Mol Wt: 469.5 Mol F: C24H25F2N5O3 Inv Status: Custom Synthesis
Chemical Name: (S,Z)-N-(4-((3,4-Difluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide
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Afatinib Impurity G
CAT No: CL-ATB-08 CAS No: NA Mol Wt: 486 Mol F: C24H25ClFN5O3 Inv Status: Custom Synthesis
Chemical Name: (S,Z)-N-(4-((4-Chloro-3-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide
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Afatinib Impurity H
CAT No: CL-ATB-09 CAS No: 2223677-64-1 Mol Wt: 442.9 Mol F: C22H20ClFN4O3 Inv Status: Custom Synthesis
Chemical Name: (S,E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)but-2-enamide
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Afatinib Impurity I
CAT No: CL-ATB-10 CAS No: NA Mol Wt: 521.8 Mol F: C22H19BrClFN4O3 Inv Status: Custom Synthesis
Chemical Name: (2S,3R,4S,5S,6R)-2-(4-Chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol
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Afatinib Impurity J
CAT No: CL-ATB-11 CAS No: 1456696-14-2 Mol Wt: 358.4 Mol F: C18H22N4O4 Inv Status: Custom Synthesis
Chemical Name: (S,E)-4-(Dimethylamino)-N-(4-oxo-7-((tetrahydrofuran-3-yl)oxy)-1,4-dihydroquinazolin-6-yl)but-2-enamide
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N-Desmethyl Afatinib
CAT No: CL-ATB-12 CAS No: 2413212-13-0 Mol Wt: 471.9 Mol F: C23H23ClFN5O3 Inv Status: Custom Synthesis
Chemical Name: (S,E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(methylamino)but-2-enamide
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Afatinib N-Oxide
CAT No: CL-ATB-13 CAS No: 2413212-13-0 Mol Wt: 501.9 Mol F: C24H25ClFN5O4 Inv Status: Custom Synthesis
Chemical Name: (S,E)-4-((4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)amino)-N,N-dimethyl-4-oxobut-2-en-1-amine oxide
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Afatinib Impurity 2
CAT No: CL-ATB-14 CAS No: 1449430-45-8 Mol Wt: 334.7 Mol F: C14H8ClFN4O3 Inv Status: Custom Synthesis
Chemical Name: 4-((3-Chloro-4-fluorophenyl)amino)-6-nitroquinazolin-7-ol
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Afatinib Impurity 3
CAT No: CL-ATB-15 CAS No: 2475094-96-1 Mol Wt: 336.7 Mol F: C14H7ClF2N4O2 Inv Status: Custom Synthesis
Chemical Name: N-(4-Chloro-3-fluorophenyl)-7-fluoro-8-nitroquinazolin-4-amine ; (3-Chloro-4-fluorophenyl)(7-fluoro-6-nitroquinazolin-4-yl)amine
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Afatinib Impurity 4
CAT No: CL-ATB-16 CAS No: 2512206-82-3 Mol Wt: 353.1 Mol F: C14H7Cl2FN4O2 Inv Status: Custom Synthesis
Chemical Name: N-(3,4-Dichlorophenyl)-7-fluoro-6-nitroquinazolin-4-amine
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Afatinib Impurity 5
CAT No: CL-ATB-17 CAS No: 179552-74-0 Mol Wt: 348.7 Mol F: C15H10ClFN4O3 Inv Status: Custom Synthesis
Chemical Name: N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-nitro-4-quinazolinamine
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Afatinib Impurity 6
CAT No: CL-ATB-18 CAS No:  2413212-07-2 Mol Wt: 340.4 Mol F: C18H17FN4O2 Inv Status: Custom Synthesis
Chemical Name: (S)-N4-(4-Fluorophenyl)-7-((tetrahydrofuran-3-yl)oxy)quinazoline-4,6-diamine
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Afatinib Impurity 7
CAT No: CL-ATB-19 CAS No: 2413212-08-3 Mol Wt: 322.4 Mol F: C18H18N4O2 Inv Status: Custom Synthesis
Chemical Name: (S)-N4-Phenyl-7-((tetrahydrofuran-3-yl)oxy)quinazoline-4,6-diamine
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Afatinib Impurity 8
CAT No: CL-ATB-20 CAS No: 2413212-09-4 Mol Wt: 356.8 Mol F: C18H17ClN4O2 Inv Status: Custom Synthesis
Chemical Name: (S)-N4-(3-Chlorophenyl)-7-((tetrahydrofuran-3-yl)oxy)quinazoline-4,6-diamine
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Afatinib Impurity 9
CAT No: CL-ATB-21 CAS No: 2413212-10-7 Mol Wt: 615.1 Mol F: C30H36ClFN6O5 Inv Status: Custom Synthesis
Chemical Name: 3-((3-Chloro-4-fluorophenyl)(6-((E)-4-(dimethylamino)but-2-enamido)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-4-yl)amino)-4-(dimethylamino)butanoic acid
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Afatinib Impurity 10
CAT No: CL-ATB-22 CAS No: NA Mol Wt: 971.9 Mol F: C48H50Cl2F2N10O6 Inv Status: Custom Synthesis
Chemical Name: (E)-N-(4-((3-Chloro-4-fluorophenyl)(4-((4-((3-chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)amino)-1-(dimethylamino)-4-oxobutan-2-yl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide
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Afatinib Impurity 11
CAT No: CL-ATB-23 CAS No: 2413212-17-4 Mol Wt: 442.9 Mol F: C22H20ClFN4O3 Inv Status: Custom Synthesis
Chemical Name: (S)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)but-3-enamide
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Afatinib Impurity 12
CAT No: CL-ATB-24 CAS No: 2121530-37-6 Mol Wt: 458.9 Mol F: C22H20ClFN4O4 Inv Status: Custom Synthesis
Chemical Name: (S,E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-hydroxybut-2-enamide
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Afatinib Impurity 13
CAT No: CL-ATB-25 CAS No:  2413212-19-6 Mol Wt: 458.9 Mol F: C22H20ClFN4O4 Inv Status: Custom Synthesis
Chemical Name: 1-(4-((3-Chloro-4-fluorophenyl)amino)-7-(((R)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-5-hydroxypyrrolidin-2-one ; Des-(4-dimethylamino-2-en-1-oxo)butylamino 6-(5-Hydroxy-pyrrolidin-2-on-1-yl) Afatinib
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Afatinib Impurity 14
CAT No: CL-ATB-26 CAS No: 2413212-21-0 Mol Wt: 504 Mol F: C24H27ClFN5O4 Inv Status: Custom Synthesis
Chemical Name: (S)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-(((R)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)-3-hydroxybutanamide
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Afatinib Impurity 15
CAT No: CL-ATB-27 CAS No: 2413212-23-2 Mol Wt: 504 Mol F: C24H27ClFN5O4 Inv Status: Custom Synthesis
Chemical Name: (R)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-(((R)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)-3-hydroxybutanamide
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Afatinib Impurity 16
CAT No: CL-ATB-28 CAS No: 2223677-60-7 Mol Wt: 402.8 Mol F: C19H16ClFN4O3 Inv Status: Custom Synthesis
Chemical Name: (S)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)formamide
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Afatinib Impurity 17
CAT No: CL-ATB-29 CAS No: NA Mol Wt: 430.9 Mol F: C21H22ClFN5O2 Inv Status: Custom Synthesis
Chemical Name: (S)-N-(1-((4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)amino)ethylidene)-N-methylmethanaminium
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Afatinib Impurity 18
CAT No: CL-ATB-30 CAS No: 2413212-25-4 Mol Wt: 451.5 Mol F: C24H26FN5O3 Inv Status: Custom Synthesis
Chemical Name: (S,E)-4-(Dimethylamino)-N-(4-((4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)but-2-enamide
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Afatinib Impurity 19
CAT No: CL-ATB-31 CAS No: 1245555-42-3 Mol Wt: 429.9 Mol F: C21H21ClFN5O2 Inv Status: Custom Synthesis
Chemical Name: (E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-4-(dimethylamino)but-2-enamide
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Afatinib Impurity 20
CAT No: CL-ATB-32 CAS No: 2085843-51-0 Mol Wt: 443.9 Mol F: C22H23ClFN5O2 Inv Status: Custom Synthesis
Chemical Name: (E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-ethoxyquinazolin-6-yl)-4-(dimethylamino)but-2-enamide
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Afatinib Impurity 21
CAT No: CL-ATB-33 CAS No: 2044709-72-8 Mol Wt: 358.4 Mol F: C18H16F2N4O2 Inv Status: Custom Synthesis
Chemical Name: (S)-N4-(3,4-Difluorophenyl)-7-((tetrahydrofuran-3-yl)oxy)quinazoline-4,6-diamine
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Afatinib Impurity 22
CAT No: CL-ATB-34 CAS No: NA Mol Wt: 601.1 Mol F: C28H29ClFN5O7 Inv Status: Custom Synthesis
Chemical Name: N-(3-Chloro-4-fluorophenyl)-N-(6-((E)-4-(dimethylamino)but-2-enamido)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-4-yl)-L-aspartic acid
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Afatinib Dimaleate
CAT No: CL-ATB-35 CAS No: 850140-73-7 Mol Wt: 485.9 : 2(116.1) Mol F: C24H25ClFN5O3 : 2(C4H4O4) Inv Status: Custom Synthesis
Chemical Name: (S,E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide dimaleate
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Afatinib Impurity 23
CAT No: CL-ATB-36 CAS No: 2223677-58-3 Mol Wt: 458.9 Mol F: C22H20ClFN4O4 Inv Status: Custom Synthesis
Chemical Name: 1-(4-((3-Chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-5-hydroxypyrrolidin-2-one
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Afatinib Impurity 24
CAT No: CL-ATB-37 CAS No: 1255078-56-8 Mol Wt: 157.2 : 36.5 Mol F: C8H15NO2 : HCl Inv Status: Custom Synthesis
Chemical Name: Ethyl (E)-4-(dimethylamino)but-2-enoate hydrochloride
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Afatinib Impurity 25
CAT No: CL-ATB-38 CAS No: 212776-19-7 Mol Wt: 143.2 Mol F: C7H13NO2 Inv Status: Custom Synthesis
Chemical Name: Methyl (E)-4-(dimethylamino)but-2-enoate
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Afatinib Impurity 26
CAT No: CL-ATB-39 CAS No: 314771-88-5 Mol Wt: 404.8 Mol F: C18H14ClFN4O4 Inv Status: Custom Synthesis
Chemical Name: (S)-N-(3-Chloro-4-fluorophenyl)-6-nitro-7-((tetrahydrofuran-3-yl)oxy)quinazolin-4-amine
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Afatinib Impurity 27
CAT No: CL-ATB-40 CAS No: 618061-76-0 Mol Wt: 552.9 Mol F: C24H27ClFN4O6P Inv Status: Custom Synthesis
Chemical Name: Diethyl (S)-(2-((4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)amino)-2-oxoethyl)phosphonate
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Afatinib Impurity 28
CAT No: CL-ATB-41 CAS No: NA Mol Wt: 458.9 Mol F: C22H20ClFN4O4 Inv Status: Custom Synthesis
Chemical Name: 1-(4-((3-Chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-2-yl)oxy)quinazolin-6-yl)-5-hydroxypyrrolidin-2-one
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Afatinib Impurity 29
CAT No: CL-ATB-42 CAS No: NA Mol Wt: 524.9 Mol F: C22H23ClFN4O6P Inv Status: Custom Synthesis
Chemical Name: Ethyl hydrogen (2-((4-((3-chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)amino)-2-oxoethyl)phosphonate
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Afatinib Impurity 32
CAT No: CL-ATB-43 CAS No: 2323570-72-3 Mol Wt: 504 Mol F: C24H27ClFN5O4 Inv Status: Custom Synthesis
Chemical Name: N-(4-((3-Chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)-3-hydroxybutanamide
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Afatinib Impurity 33
CAT No: CL-ATB-44 CAS No: 162012-69-3 Mol Wt: 209.1 Mol F: C8H4FN3O3 Inv Status: Custom Synthesis
Chemical Name: 7-Fluoro-6-nitroquinazolin-4(3H)-one
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Afatinib Impurity 34
CAT No: CL-ATB-45 CAS No: 16499-57-3 Mol Wt: 164.1 Mol F: C8H5FN2O Inv Status: Custom Synthesis
Chemical Name: 7-Fluoroquinazolin-4(3H)-one
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Afatinib Impurity 35
CAT No: CL-ATB-46 CAS No: NA Mol Wt: 320.2 : 36.5 Mol F: C14H7F3N4O2 : HCl Inv Status: Custom Synthesis
Chemical Name: N-(3,4-difluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine hydrochloride
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Afatinib Impurity 36
CAT No: CL-ATB-47 CAS No: 2044709-79-5 Mol Wt: 391.3 Mol F: C18H16Cl2N4O2 Inv Status: Custom Synthesis
Chemical Name: (S)-N4-(3,4-dichlorophenyl)-7-((tetrahydrofuran-3-yl)oxy)quinazoline-4,6-diamine
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Afatinib Impurity 37
CAT No: CL-ATB-48 CAS No: 2223677-61-8 Mol Wt: 415.9 Mol F: C20H19ClFN5O2 Inv Status: Custom Synthesis
Chemical Name: (E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-hydroxyquinazolin-6-yl)-4-(dimethylamino)but-2-enamide
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Afatinib Impurity 38
CAT No: CL-ATB-49 CAS No: 2223677-65-2 Mol Wt: 803.6 Mol F: C38H30Cl2F2N8O6 Inv Status: Custom Synthesis
Chemical Name: N1,N2-bis(4-((3-chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)oxalamide
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Afatinib Impurity 39
CAT No: CL-ATB-50 CAS No: 2223677-66-3 Mol Wt: 473.9 Mol F: C22H21ClFN5O4 Inv Status: Custom Synthesis
Chemical Name: (S)-N1-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-N2,N2-dimethyloxalamide
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Afatinib Impurity 40
CAT No: CL-ATB-51 CAS No: NA Mol Wt: 416.8 Mol F: C20H18ClFN4O3 Inv Status: Custom Synthesis
Chemical Name: (S)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)acetamide
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Afatinib Impurity 41
CAT No: CL-ATB-52 CAS No: 2475095-50-0 Mol Wt: 336.7 Mol F: C14H7ClF2N4O2 Inv Status: Custom Synthesis
Chemical Name: N-(4-Chloro-3-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine
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Afatinib Impurity 42
CAT No: CL-ATB-53 CAS No: 2413212-27-6 Mol Wt: 588 Mol F: C27H27ClFN5O7 Inv Status: Custom Synthesis
Chemical Name: (S,E)-2-((3-chloro-4-fluorophenyl)(6-(4-(dimethylamino)but-2-enamido)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-4-yl)amino)malonic acid
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Afatinib Impurity 43
CAT No: CL-ATB-54 CAS No: 402855-03-2 Mol Wt: 374.8 Mol F: C18H16ClFN4O2 Inv Status: Custom Synthesis
Chemical Name: (R)-N4-(3-chloro-4-fluorophenyl)-7-((tetrahydrofuran-3-yl)oxy)quinazoline-4,6-diamine
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Afatinib Bis-dimethylamino Impurity
CAT No: CL-ATB-55 CAS No: 2414260-31-2 Mol Wt: 531 Mol F: C26H32ClFN6O3 Inv Status: Custom Synthesis
Chemical Name: N-(4-((3-chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-3,4-bis(dimethylamino)butanamide
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Afatinib Butoxy Analog
CAT No: CL-ATB-56 CAS No: NA Mol Wt: 472 Mol F: C24H27ClFN5O2 Inv Status: Custom Synthesis
Chemical Name: (E)-N-(7-Butoxy-4- ((3-chloro-4fluoroophenyl)amino)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide
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Afatinib Sulfonic Acid Analog
CAT No: CL-ATB-57 CAS No: 2283295-16-7 Mol Wt: 568 Mol F: C24H27ClFN5O6S Inv Status: Custom Synthesis
Chemical Name: 4((4-((3-Chloro-4-fluorophenyl) amino)-7-(((S)-tetrahydrofuran-3-yl) oxy) quinazolin-6-yl)amino)-1-(dimethylamino)-4-oxobutane-2-sulfonic acid
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Afatinib D4
CAT No: CL-ATB-58 CAS No: NA Mol Wt: 490 Mol F: C24H21D4ClFN5O3 Inv Status: Custom Synthesis
Chemical Name: (S,E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl-2,2,5,5-d4)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide
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Afatinib D6
CAT No: CL-ATB-59 CAS No: 1313874-96-2 Mol Wt: 492 Mol F: C24H19D6ClFN5O3 Inv Status: Custom Synthesis
Chemical Name: (S,E)-4-(Bis(methyl-d3)amino)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)but-2-enamide
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Afatinib 13C6
CAT No: CL-ATB-60 CAS No: NA Mol Wt: 491.9 Mol F: C1813C6H25ClFN5O3 Inv Status: Custom Synthesis
Chemical Name: (S,E)-N-(4-((3-chloro-4-fluorophenyl-1,2,3,4,5,6-13C6)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide

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