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Adapalene is a topical retinoid used for the treatment of acne vulgaris. It works by modulating cell differentiation and keratinization, helping to prevent comedone formation. It has anti-inflammatory properties and is less irritating than older retinoids like tretinoin. Adapalene is available over-the-counter in many countries.

Cleanchem is a trusted provider of premium pharmaceutical reference materials, specializing in Adapalene and its associated compounds. Our catalog includes pharmacopeial and non-pharmacopeial Adapalene impurities, metabolites, nitrosamine derivatives (N-NO compounds), and stable isotope-labeled products. These reference standards play a critical role in pharmaceutical R&D, supporting activities such as product formulation, ANDA and DMF submissions, quality assurance, analytical method development, and stability assessments.
All Adapalene-related substances undergo comprehensive characterization and are delivered with complete Certificates of Analysis and supporting analytical documentation to ensure regulatory adherence. Upon request, we can offer EP/USP traceable standards. Our products are routinely re-evaluated to maintain consistent quality and performance.

Adapalene

CAT No: CL-ADPL-01 CAS No: NA Mol Wt: 412.5 Mol F: C28H28O3 Inv Status: Custom Synthesis

Chemical Name: 6-(4-Methoxy-3-tricyclo[3.3.1.13,7]dec-1-ylphenyl)naphthalene-2-carboxylic acid ; 6-[3-(1-Adamantyl)-4-methoxyphenyl]-2-naphthoic acid (as per USP)

Adapalene EP Impurity A

CAT No: CL-ADPL-02 CAS No: 932033-58-4 Mol Wt: 342.3 Mol F: C22H14O4 Inv Status: In Stock

Chemical Name: 2,2??-Binaphthalene-6,6??-dicarboxylic acid ; 2,2??inaphthyl-6,6??icarboxylic acid (as per USP)

Adapalene EP Impurity B

CAT No: CL-ADPL-03 CAS No: 1346599-76-5 Mol Wt: 428.5 Mol F: C28H28O4 Inv Status: Custom Synthesis

Chemical Name: 6-[3-(3-Hydroxytricyclo[3.3.1.13,7]dec-1-yl)-4-methoxyphenyl]naphthalene-2-carboxylic acid ; 6-[3-(3-Hydroxyadamant-1-yl)-4-methoxyphenyl]-2-naphthoic acid (as per USP)

Adapalene EP Impurity C

CAT No: CL-ADPL-04 CAS No: 43109-77-9 Mol Wt: 242.4 Mol F: C17H22O Inv Status: Custom Synthesis

Chemical Name: 1-(2-Methoxyphenyl)tricyclo[3.3.1.13,7]decane ; 2-(Adamant-1-yl)methoxybenzene (as per USP)

Adapalene EP Impurity D

CAT No: CL-ADPL-05 CAS No: 932033-57-3 Mol Wt: 482.7 Mol F: C34H42O2 Inv Status: Custom Synthesis

Chemical Name: 1,1??-[4,4??-Bis(methoxy)biphenyl-3,3??-diyl]bis(tricyclo[3.3.1.13,7]decane) ; 4,4??imethoxy-3,3??i(adamant-1-yl)biphenyl (as per USP)

Adapalene Related Compound B

CAT No: CL-ADPL-06 CAS No: 106685-41-0 Mol Wt: 426.5 Mol F: C29H30O3 Inv Status: Custom Synthesis

Chemical Name: Methyl 6-[3-(1-Adamantyl)-4-methoxyphenyl]-2-naphthoate (as per USP)

O-Desmethyl Adapalene

CAT No: CL-ADPL-07 CAS No: 125316-60-1 Mol Wt: 398.5 Mol F: C27H26O3 Inv Status: Custom Synthesis

Chemical Name: 6-(4-Hydroxy-3-tricyclo[3.3.1.13,7]dec-1-ylphenyl)-2-naphthalenecarboxylic Acid

2-(1-Adamantyl)-4-Bromoanisole

CAT No: CL-ADPL-08 CAS No: 104224-63-7 Mol Wt: 321.2 Mol F: C17H21BrO Inv Status: Custom Synthesis

Chemical Name: 1-(5-Bromo-2-methoxyphenyl)-tricyclo[3.3.1.13,7]decane

Adapalene Dimer Impurity

CAT No: CL-ADPL-09 CAS No: NA Mol Wt: 688.8 Mol F: C46H40O6 Inv Status: Custom Synthesis

Chemical Name: 6,6'-(((1S,2R,3S,5R,7S)-Adamantane-1,2-diyl)bis(4-methoxy-3,1-phenylene))bis(2-naphthoic acid)

Adapalene Impurity 1

CAT No: CL-ADPL-10 CAS No: 132292-17-2 Mol Wt: 278.3 Mol F: C18H14O3 Inv Status: Custom Synthesis

Chemical Name: 6-(4-Methoxyphenyl)-2-naphthoic acid

Adapalene Related Compound A

CAT No: CL-ADPL-11 CAS No: 33626-98-1 Mol Wt: 265.1 Mol F: C12H9BrO2 Inv Status: In Stock

Chemical Name: Methyl 6-bromo-2-naphthoate (as per USP)

2-(Adamantan-1-yl)-4-Bromophenol

CAT No: CL-ADPL-12 CAS No: 104224-68-2 Mol Wt: 307.2 Mol F: C16H19BrO Inv Status: Custom Synthesis

Chemical Name: 2-(1-Adamantyl)-4-bromophenol

2-Napthoic Acid

CAT No: CL-ADPL-13 CAS No: 93-09-4 Mol Wt: 172.2 Mol F: C11H8O2 Inv Status: Custom Synthesis

Chemical Name: 2-Napthoic Acid

6-Bromo-2-Naphthoic Acid

CAT No: CL-ADPL-14 CAS No: 5773-80-8 Mol Wt: 251.1 Mol F: C11H7BrO2 Inv Status: Custom Synthesis

Chemical Name: 6-Bromo-2-naphthoic acid

2-Hydroxy Adapalene Methyl Ester

CAT No: CL-ADPL-15 CAS No: NA Mol Wt: 442.6 Mol F: C29H30O4 Inv Status: Custom Synthesis

Chemical Name: Methyl 6-(3-(3-hydroxyadamantan-1-yl)-4-methoxyphenyl)-2-naphthoate

Dihydroxy Adamantane

CAT No: CL-ADPL-16 CAS No: 28996-06-7 Mol Wt: 168.2 Mol F: C10H16O2 Inv Status: Custom Synthesis

Chemical Name: (1s,3s,5R,7S)-Adamantane-1,2-diol

Methyl 7-Bromo-1-Naphthoate

CAT No: CL-ADPL-17 CAS No: 93353-67-4 Mol Wt: 265.1 Mol F: C12H9BrO2 Inv Status: Custom Synthesis

Chemical Name: Methyl 7-bromo-1-naphthoate

Methyl 2-naphthoate

CAT No: CL-ADPL-18 CAS No: 2459-25-8 Mol Wt: 186.2 Mol F: C12H10O2 Inv Status: Custom Synthesis

Chemical Name: Methyl 2-naphthoate

Adapalene Impurity 2

CAT No: CL-ADPL-19 CAS No: 161912-38-5 Mol Wt: 370.4 Mol F: C24H18O4 Inv Status: Custom Synthesis

Chemical Name: Dimethyl [2,2'-binaphthalene]-6,6'-dicarboxylate

Adapalene Impurity 3

CAT No: CL-ADPL-20 CAS No: 100751-63-1 Mol Wt: 237.1 Mol F: C11H9BrO Inv Status: Custom Synthesis

Chemical Name: (6-Bromonaphthalen-2-yl)methanol

Adapalene Impurity 4

CAT No: CL-ADPL-21 CAS No: NA Mol Wt: 442.5 Mol F: C28H26O5 Inv Status: Custom Synthesis

Chemical Name: 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-1,4-dioxo-1,4-dihydronaphthalene-2-carboxylic acid

Adapalene Impurity 5

CAT No: CL-ADPL-22 CAS No: NA Mol Wt: 400.5 Mol F: C27H28O3 Inv Status: Custom Synthesis

Chemical Name: 3'-((3r,5r,7r)-Adamantan-1-yl)-4'-methoxy-3-((E)-3-oxoprop-1-en-1-yl)-[1,1'-biphenyl]-4-carbaldehyde

Adapalene Impurity 6

CAT No: CL-ADPL-23 CAS No: 128272-36-6 Mol Wt: 292.3 Mol F: C19H16O3 Inv Status: Custom Synthesis

Chemical Name: Methyl 6-(4-methoxyphenyl)-2-naphthoate

Adapalene Impurity 7

CAT No: CL-ADPL-24 CAS No: 106685-43-2 Mol Wt: 412.5 Mol F: C28H28O3 Inv Status: Custom Synthesis

Chemical Name: Methyl 6-(3-((3r,5r,7r)-adamantan-1-yl)-4-hydroxyphenyl)-2-naphthoate

Adapalene Impurity 8

CAT No: CL-ADPL-25 CAS No: 107430-57-9 Mol Wt: 278.3 Mol F: C18H14O3 Inv Status: Custom Synthesis

Chemical Name: 4-(6-Methoxynaphthalen-2-yl)benzoic acid

Adapalene Impurity 9

CAT No: CL-ADPL-26 CAS No: 7314-85-4 Mol Wt: 215.1 Mol F: C10H15Br Inv Status: Custom Synthesis

Chemical Name: (1r,3r,5r,7r)-2-Bromoadamantane

Adapalene Impurity 10

CAT No: CL-ADPL-27 CAS No: NA Mol Wt: 321.3 Mol F: C17H21BrO Inv Status: Custom Synthesis

Chemical Name: 1-(3-Bromo-2-methoxyphenyl)adamantane

Adapalene Impurity 11

CAT No: CL-ADPL-28 CAS No: NA Mol Wt: 611.6 Mol F: C36H35BrO4 Inv Status: Custom Synthesis

Chemical Name: Methyl 6-(3-((1R,2R,3R,5R,7S)-2-(5-bromo-2-methoxyphenyl)adamantan-1-yl)-4-methoxyphenyl)-2-naphthoate

Adapalene Impurity 12

CAT No: CL-ADPL-29 CAS No: 932033-56-2 Mol Wt: 506.3 Mol F: C24H26Br2O2 Inv Status: Custom Synthesis

Chemical Name: 1,3-Bis(5-bromo-2-methoxyphenyl)adamantane

Adapalene D3

CAT No: CL-ADPL-30 CAS No: 1276433-89-6 Mol Wt: 415.6 Mol F: C28H25D3O3 Inv Status: Custom Synthesis

Chemical Name: 6-(3-((3r,5r,7r)-Adamantan-1-yl)-4-(methoxy-d3)phenyl)-2-naphthoic acid

Type:Impurity Reference Standard

Total Products: 30

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