Cobicistat is a pharmacokinetic enhancer used in combination with antiretroviral drugs to boost their effectiveness. It works by inhibiting the enzyme cytochrome P450 3A (CYP3A), which is responsible for metabolizing many drugs, thereby increasing the blood levels of co-administered drugs. Cobicistat is commonly used in the treatment of HIV infections to increase the bioavailability of other antiretroviral drugs like atazanavir and darunavir. Side effects may include gastrointestinal discomfort, liver enzyme elevations, and kidney problems.
Cleanchem is a trusted provider of premium pharmaceutical reference materials, specializing in Cobicistat and its associated compounds. Our catalog includes pharmacopeial and non-pharmacopeial Cobicistat impurities, metabolites, nitrosamine derivatives (N-NO compounds), and stable isotope-labeled products. These reference standards play a critical role in pharmaceutical R&D, supporting activities such as product formulation, ANDA and DMF submissions, quality assurance, analytical method development, and stability assessments.
All Cobicistat-related substances undergo comprehensive characterization and are delivered with complete Certificates of Analysis and supporting analytical documentation to ensure regulatory adherence. Upon request, we can offer EP/USP traceable standards. Our products are routinely re-evaluated to maintain consistent quality and performance.
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