Amsacrine is an antineoplastic agent used mainly in the treatment of acute leukemias. It acts by intercalating into DNA and inhibiting topoisomerase II, resulting in impaired DNA replication and repair. It is usually administered intravenously under close supervision. Common adverse effects include bone marrow suppression, nausea, and cardiac toxicity.
Cleanchem is a trusted provider of premium pharmaceutical reference materials, specializing in Amsacrine and its associated compounds. Our catalog includes pharmacopeial and non-pharmacopeial Amsacrine impurities, metabolites, nitrosamine derivatives (N-NO compounds), and stable isotope-labeled products. These reference standards play a critical role in pharmaceutical R&D, supporting activities such as product formulation, ANDA and DMF submissions, quality assurance, analytical method development, and stability assessments.
All Amsacrine-related substances undergo comprehensive characterization and are delivered with complete Certificates of Analysis and supporting analytical documentation to ensure regulatory adherence. Upon request, we can offer EP/USP traceable standards. Our products are routinely re-evaluated to maintain consistent quality and performance.
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